CYYR1_MOUSE
ID CYYR1_MOUSE Reviewed; 165 AA.
AC Q8VIH7; Q499D9;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Cysteine and tyrosine-rich protein 1;
DE AltName: Full=Proline-rich domain-containing protein;
DE Flags: Precursor;
GN Name=Cyyr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=12062809; DOI=10.1016/s0378-1119(02)00550-4;
RA Vitale L., Casadei R., Canaider S., Lenzi L., Strippoli P., D'Addabbo P.,
RA Giannone S., Carinci P., Zannotti M.;
RT "Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human
RT chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and
RT defines a new family of highly conserved vertebrate-specific genes.";
RL Gene 290:141-151(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12036297; DOI=10.1006/geno.2002.6781;
RA Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B.,
RA Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S.,
RA Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E.;
RT "Nineteen additional unpredicted transcripts from human chromosome 21.";
RL Genomics 79:824-832(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CYYR1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF442733; AAL35295.1; -; mRNA.
DR EMBL; AY061854; AAL35738.1; -; mRNA.
DR EMBL; AC154622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT025589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC099957; AAH99957.1; -; mRNA.
DR EMBL; BC125594; AAI25595.1; -; mRNA.
DR EMBL; BC125596; AAI25597.1; -; mRNA.
DR CCDS; CCDS28286.1; -.
DR RefSeq; NP_659102.1; NM_144853.3.
DR RefSeq; XP_006523068.1; XM_006523005.1.
DR AlphaFoldDB; Q8VIH7; -.
DR STRING; 10090.ENSMUSP00000109811; -.
DR iPTMnet; Q8VIH7; -.
DR PhosphoSitePlus; Q8VIH7; -.
DR MaxQB; Q8VIH7; -.
DR PaxDb; Q8VIH7; -.
DR PRIDE; Q8VIH7; -.
DR ProteomicsDB; 279144; -.
DR Antibodypedia; 60029; 71 antibodies from 16 providers.
DR DNASU; 224405; -.
DR Ensembl; ENSMUST00000114174; ENSMUSP00000109811; ENSMUSG00000041134.
DR GeneID; 224405; -.
DR KEGG; mmu:224405; -.
DR UCSC; uc007ztu.2; mouse.
DR CTD; 116159; -.
DR MGI; MGI:2152187; Cyyr1.
DR VEuPathDB; HostDB:ENSMUSG00000041134; -.
DR eggNOG; ENOG502S121; Eukaryota.
DR GeneTree; ENSGT00500000044986; -.
DR HOGENOM; CLU_143594_0_0_1; -.
DR InParanoid; Q8VIH7; -.
DR OMA; YSYDYEM; -.
DR OrthoDB; 1592053at2759; -.
DR PhylomeDB; Q8VIH7; -.
DR TreeFam; TF332064; -.
DR BioGRID-ORCS; 224405; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Cyyr1; mouse.
DR PRO; PR:Q8VIH7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8VIH7; protein.
DR Bgee; ENSMUSG00000041134; Expressed in brain blood vessel and 172 other tissues.
DR ExpressionAtlas; Q8VIH7; baseline and differential.
DR Genevisible; Q8VIH7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR022640; CYYR1.
DR PANTHER; PTHR38490; PTHR38490; 1.
DR Pfam; PF10873; CYYR1; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..165
FT /note="Cysteine and tyrosine-rich protein 1"
FT /id="PRO_0000021055"
FT TOPO_DOM 30..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 125..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 36
FT /note="H -> R (in Ref. 1; AAL35295)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 165 AA; 18044 MW; 169DC2BF02BCFDD4 CRC64;
MDALRLPRRP GVLLPKLILL FVYAGDCLAQ CGKECHSYCC DGSTPYCCSY YAYIGNILSG
TAIAGIVFGI VFIMGVIAGI AICICMCMKN NRGTRVGVIR AAHINAISYP MAPPPYTYDH
EMEYRTDLPP PYSAAPQASA QRSPPPPYPG NPRKYSSSQN RIRDN
