ID   CZCB_ALCSC              Reviewed;         520 AA.
AC   P94176;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Cation efflux system protein CzcB;
GN   Name=czcB;
OS   Alcaligenes sp. (strain CT14).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Alcaligenes.
OX   NCBI_TaxID=68998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8829543; DOI=10.1271/bbb.60.699;
RA   Kunito T., Kusano T., Oyaizu H., Senoo K., Kanazawa S., Matsumoto S.;
RT   "Cloning and sequence analysis of czc genes in Alcaligenes sp. strain
RT   CT14.";
RL   Biosci. Biotechnol. Biochem. 60:699-704(1996).
CC   -!- FUNCTION: CzcA and CzcB together would act in zinc efflux nearly as
CC       effectively as the complete czc efflux system (CzcABC). The CzcB
CC       protein is thought to funnel zinc cations to the CzcA transport
CC       protein.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
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DR   EMBL; D67044; BAA11060.1; -; Genomic_DNA.
DR   PIR; JC4699; JC4699.
DR   AlphaFoldDB; P94176; -.
DR   SMR; P94176; -.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
DR   InterPro; IPR005695; Co/Zn/Cd_resistance_CzcB.
DR   InterPro; IPR043602; CusB_dom_1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF00529; CusB_dom_1; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR00999; 8a0102; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cadmium resistance; Cobalt; Plasmid; Transport; Zinc.
FT   CHAIN           1..520
FT                   /note="Cation efflux system protein CzcB"
FT                   /id="PRO_0000201868"
FT   REGION          28..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  54574 MW;  AF7000ABA955C224 CRC64;
     MAISNKQKAA IAAIVLVGGV ATGGVLLSGR SAPEEQGGHS ESKGHGDTEH HGKQAAEADH
     KDDKSHGDGE HHEVKKGPNG GALFSRDGYD VEIGTAESKG EARIRLWVSK SGKAVANGVA
     ATGQLVRATG ESQALKFVVS GDALESQQPV AEPHVFDVTA NVTLPGSSSP LAVRLSKEEG
     KIELTADQLA KTGVVVQTAG SAKVQAGVQF PGEIRFNEDK TAHVVPRLAG VVESVPANIG
     QQVKKGQVLA VIASTGLSDQ RSELLAAQKR LDLARVTYDR EKKLWEQKIS ADEDYLSARN
     ALQEAQISVQ NAQQKLTAIG ASNSSTALNR YELRAPFAGM IVEKHISLGE AVADNANVFT
     LSDLSSVWAE FVVSAKDVER VRIGEKASIN SASSDVKADG TVSYVGSLLG EQTRTAKARV
     TLTNPQMAWR PGLFVTVDVF GADVEVPVAV KTEAVQDVNG ESVVFVAVQG GFVPQPVKVG
     RTNGKVIEIV EGLKPGARYA AANSFVLKAE LGKSSAEHGH