ID   CZCD_ALCSC              Reviewed;         316 AA.
AC   P94178;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Cation efflux system protein CzcD;
GN   Name=czcD;
OS   Alcaligenes sp. (strain CT14).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Alcaligenes.
OX   NCBI_TaxID=68998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8829543; DOI=10.1271/bbb.60.699;
RA   Kunito T., Kusano T., Oyaizu H., Senoo K., Kanazawa S., Matsumoto S.;
RT   "Cloning and sequence analysis of czc genes in Alcaligenes sp. strain
RT   CT14.";
RL   Biosci. Biotechnol. Biochem. 60:699-704(1996).
CC   -!- FUNCTION: Necessary for activation of the czc determinant.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; D67044; BAA11062.1; -; Genomic_DNA.
DR   PIR; JC4701; JC4701.
DR   AlphaFoldDB; P94178; -.
DR   SMR; P94178; -.
DR   PRIDE; P94178; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   3: Inferred from homology;
KW   Cadmium; Cell membrane; Cobalt; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..316
FT                   /note="Cation efflux system protein CzcD"
FT                   /id="PRO_0000206106"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  33741 MW;  D677C1B4A1E96462 CRC64;
     MGAGHSHDHP GGNERSLKIA LALTGTFLIA EVVGGVMTKS LALISDAAHM LTDTVALAIA
     LAAIAIAKRP ADKKRTFGYY RFEILAAAFN ALLLFGVAIY ILYEAYLRLK SPPQIESTGM
     FVVAVLGLII NLISMRMLSS GQSSSLNVKG AYLEVWSDLL GSVGVIAGAI IIRFTGWAWV
     DSAIAVLIGL WVLPRTWFLL KSSLNVLLEG VPDDVDLAEV EKQILATPGV KSFHDLHIWA
     LTSGKASLTV HVVNDTAVNP EMEVLPELKQ MLADKFDITH VTIQFELAPC EQADAAQHFN
     ASPALVGSKS LAAGGN