ID   CZCD_BACVZ              Reviewed;         313 AA.
AC   A7Z1S6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Cadmium, cobalt and zinc/H(+)-K(+) antiporter;
GN   Name=czcD; OrderedLocusNames=RBAM_005600;
OS   Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)
OS   (Bacillus amyloliquefaciens subsp. plantarum).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus amyloliquefaciens group.
OX   NCBI_TaxID=326423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42;
RX   PubMed=17704766; DOI=10.1038/nbt1325;
RA   Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K.,
RA   Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H.,
RA   Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H.,
RA   Strittmatter A., Gottschalk G., Borriss R.;
RT   "Comparative analysis of the complete genome sequence of the plant growth-
RT   promoting bacterium Bacillus amyloliquefaciens FZB42.";
RL   Nat. Biotechnol. 25:1007-1014(2007).
CC   -!- FUNCTION: Involved in divalent cation and potassium homeostasis in the
CC       cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in
CC       exchange for potassium and H(+) ions (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR   EMBL; CP000560; ABS72952.1; -; Genomic_DNA.
DR   RefSeq; WP_012116909.1; NC_009725.2.
DR   AlphaFoldDB; A7Z1S6; -.
DR   SMR; A7Z1S6; -.
DR   STRING; 326423.RBAM_005600; -.
DR   EnsemblBacteria; ABS72952; ABS72952; RBAM_005600.
DR   KEGG; bay:RBAM_005600; -.
DR   HOGENOM; CLU_013430_0_0_9; -.
DR   OMA; RTWGWAR; -.
DR   Proteomes; UP000001120; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   Gene3D; 3.30.70.1350; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027470; Cation_efflux_CTD.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   Pfam; PF16916; ZT_dimer; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   3: Inferred from homology;
KW   Cadmium; Cell membrane; Cobalt; Cobalt transport; Ion transport; Membrane;
KW   Potassium; Potassium transport; Transmembrane; Transmembrane helix;
KW   Transport; Zinc; Zinc transport.
FT   CHAIN           1..313
FT                   /note="Cadmium, cobalt and zinc/H(+)-K(+) antiporter"
FT                   /id="PRO_0000337068"
FT   TOPO_DOM        1..14
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..45
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..117
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..313
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   313 AA;  34099 MW;  7E462A1DD9C32590 CRC64;
     MGHNHNHAGG SNKKVLLISF IMITGYMIIE AIGGFLTNSL ALLSDAGHML SDSISLMVAL
     IAFKLAEKKA SHHKTFGYKR FEILAAVING VALILISLYI IYEAIKRFSH PPEVATTGML
     TISIIGLAVN ILVAWIMLNG GDTKNNLNIR GAYLHVISDM LGSIGAILAA ILIIFFGWSW
     ADPAASVIVA ILVLRSGYHV TKDSIHVLME GTPGNIDVTD IIHTIEETEG IQSIHDLHIW
     SITSGLNALS CHAVVNDQLT ISESESILRK IEHELGDKGI THVTIQMETA AHNHDNTILC
     QSQTENPRDH HHH