ID   CZCI_CUPMC              Reviewed;         115 AA.
AC   Q44009; O07951;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Cobalt-zinc-cadmium resistance protein CzcI;
DE   AltName: Full=Cation efflux system protein CzcI;
DE   Flags: Precursor;
GN   Name=czcI; OrderedLocusNames=Rmet_5983.1;
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS   CH34) (Ralstonia metallidurans).
OG   Plasmid pMOL30.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1459958; DOI=10.1128/jb.174.24.8102-8110.1992;
RA   Nies D.H.;
RT   "CzcR and CzcD, gene products affecting regulation of resistance to cobalt,
RT   zinc, and cadmium (czc system) in Alcaligenes eutrophus.";
RL   J. Bacteriol. 174:8102-8110(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, INDUCTION, AND
RP   DISCUSSION OF FUNCTION.
RX   PubMed=7766206; DOI=10.1007/bf01569896;
RA   Diels L., Dong Q., van der Lelie D., Baeyens W., Mergeay M.;
RT   "The czc operon of Alcaligenes eutrophus CH34: from resistance mechanism to
RT   the removal of heavy metals.";
RL   J. Ind. Microbiol. 14:142-153(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA   Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA   Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT   master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- FUNCTION: Component of the czc cation-efflux system that confers
CC       resistance to cobalt, zinc and cadmium. May have a regulatory function.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- INDUCTION: By zinc, cobalt and cadmium (zinc being the best and cadmium
CC       being the worst inducer). {ECO:0000269|PubMed:7766206}.
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DR   EMBL; X71400; CAA50524.1; -; Genomic_DNA.
DR   EMBL; X98451; CAA67081.1; -; Genomic_DNA.
DR   EMBL; CP000354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_011229345.1; NC_007971.2.
DR   RefSeq; YP_145592.1; NC_006466.1.
DR   AlphaFoldDB; Q44009; -.
DR   GeneID; 60820447; -.
DR   Proteomes; UP000002429; Plasmid pMOL30.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cadmium resistance; Cobalt; Periplasm; Plasmid; Reference proteome; Signal;
KW   Zinc.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..115
FT                   /note="Cobalt-zinc-cadmium resistance protein CzcI"
FT                   /id="PRO_0000021057"
FT   REGION          93..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  13266 MW;  9B8AC92FB8719834 CRC64;
     MRRFVLIFVL LILPFQFSWA AAARYCQHEK ATATWHLGHH EHRHQQPEGK TDAEKKPFVD
     TDCGVCHLVS LPFVYGQTQD VLIANRVEVT DTQHSSEFSS LNARAPDRPQ WQRLA