ID   CZCR_CUPMC              Reviewed;         225 AA.
AC   Q44006; Q58AM1;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Transcriptional activator protein CzcR;
GN   Name=czcR; OrderedLocusNames=Rmet_5978;
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS   CH34) (Ralstonia metallidurans).
OG   Plasmid pMOL30.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9044283; DOI=10.1046/j.1365-2958.1997.d01-1866.x;
RA   van der Lelie D., Schwuchow T., Schwidetzky T., Wuertz S., Baeyens W.,
RA   Mergeay M., Nies D.H.;
RT   "Two-component regulatory system involved in transcriptional control of
RT   heavy-metal homoeostasis in Alcaligenes eutrophus.";
RL   Mol. Microbiol. 23:493-503(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Monchy S., van der Lelie D., Vallaeys T., Taghavi S., Benotmane M.,
RA   McCorkle S., Dunn J., Lapidus A., Mergeay M.;
RT   "Sequence and features of the Ralstonia metallidurans CH34 heavy metals
RT   plasmids pMOL28 and pMOL30.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA   Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA   Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT   master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- FUNCTION: Member of the two-component regulatory system CzcS/CzcR
CC       involved in the control of cobalt, zinc and cadmium homeostasis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: By cadmium, lead, and zinc.
CC   -!- PTM: Phosphorylated by CzcS. {ECO:0000305}.
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DR   EMBL; X71400; CAI11246.1; -; Genomic_DNA.
DR   EMBL; X98451; CAA67086.1; -; Genomic_DNA.
DR   EMBL; CP000354; ABF12837.1; -; Genomic_DNA.
DR   RefSeq; WP_011229348.1; NC_007971.2.
DR   RefSeq; YP_145597.1; NC_006466.1.
DR   AlphaFoldDB; Q44006; -.
DR   SMR; Q44006; -.
DR   EnsemblBacteria; ABF12837; ABF12837; Rmet_5978.
DR   KEGG; rme:Rmet_5978; -.
DR   HOGENOM; CLU_000445_30_1_4; -.
DR   OMA; EFSILWV; -.
DR   OrthoDB; 1020672at2; -.
DR   Proteomes; UP000002429; Plasmid pMOL30.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR006291; PcoR.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   TIGRFAMs; TIGR01387; cztR_silR_copR; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cadmium; Cobalt; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Plasmid; Reference proteome; Transcription; Transcription regulation;
KW   Two-component regulatory system; Zinc.
FT   CHAIN           1..225
FT                   /note="Transcriptional activator protein CzcR"
FT                   /id="PRO_0000081087"
FT   DOMAIN          2..115
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        123..221
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   225 AA;  25540 MW;  8ABDDFF2B140A017 CRC64;
     MRVLVVEDEP RTAEYLQKGL SESGFVVDIA NNGGDGLHMA EETDYDVIIL DVMLPGMDGW
     TVIKSIRSKS ETPVLFLTAL DDVADRVRGF ELGADDYLVK PFAFAELLAR IRRCLRQSTS
     KESERLRIAD LDIDVLGRRV FRGTTRIELT NQEFSLLHLL MRRRGEVLSR TTIASQVWGV
     NFDTDTNVVD VAIRRLRSKV DDPFDQKLIH TVRGMGYVLD PERGR