ID   CZF1_CANAW              Reviewed;         388 AA.
AC   P28875; C4YGH0;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Zinc finger protein 1;
GN   Name=CZF1; ORFNames=CAWG_03147;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=1409649; DOI=10.1073/pnas.89.20.9410;
RA   Whiteway M., Dignard D., Thomas D.Y.;
RT   "Dominant negative selection of heterologous genes: isolation of Candida
RT   albicans genes that interfere with Saccharomyces cerevisiae mating factor-
RT   induced cell cycle arrest.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:9410-9414(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Perhaps a regulatory role. May be involved in transcriptional
CC       activation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; M76586; AAA34377.2; -; Genomic_DNA.
DR   EMBL; CH672349; EEQ44852.1; -; Genomic_DNA.
DR   PIR; C47211; C47211.
DR   PIR; S27407; S27407.
DR   AlphaFoldDB; P28875; -.
DR   SMR; P28875; -.
DR   STRING; 5476.P28875; -.
DR   EnsemblFungi; EEQ44852; EEQ44852; CAWG_03147.
DR   VEuPathDB; FungiDB:CAWG_03147; -.
DR   HOGENOM; CLU_705961_0_0_1; -.
DR   OMA; LRLNCTW; -.
DR   Proteomes; UP000001429; Chromosome 4, Supercontig 1.4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   4: Predicted;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..388
FT                   /note="Zinc finger protein 1"
FT                   /id="PRO_0000114946"
FT   DNA_BIND        318..345
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          348..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        282..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..367
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  43763 MW;  28C6CA69E73F1985 CRC64;
     MSSIPNINWN DPNNGKSNTS RQSQPQPQLP SNVSPPNSRA VPTSGSIGGP QYGSSQFSNE
     YSRNPNTIGG PPFPLQSNQR GYMPNTGYPV QQTAQQRSGD KLQQVHSQQQ QQQQQQQQPL
     YQQYPPQSVG YLAGDVYNPQ HQEYVQMNQL PNQHYNLQQR QQAQGQQLKS QLNEQNAMMS
     ASTQQYPVQD FTNPYPNAQN PAEQQQQQQP LRTQSQQWDG YQSQPLYSAA GNTIPSSIQQ
     QIPPQNLSPS EQQQVKQQQP SPPEQGTKKK PGRKPKLRKL SESSSETPQV PKTASSSSSS
     PTAVNSGKPI TKRSRMGCLT CRQRKKRCCE TRPRCTECTR LRLNCTWPKP GTEHKNKPKD
     QKDDENTIEH AEFGRIKVLR GIVEYRSK