ID   C_BPPHS                 Reviewed;          86 AA.
AC   P69172; P03635;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Protein C;
GN   Name=C;
OS   Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174).
OC   Viruses; Monodnaviria; Sangervirae; Phixviricota; Malgrandaviricetes;
OC   Petitvirales; Microviridae; Bullavirinae; Sinsheimervirus.
OX   NCBI_TaxID=1217068;
OH   NCBI_TaxID=498388; Escherichia coli C.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=870828; DOI=10.1038/265687a0;
RA   Sanger F., Air G.M., Barrell B.G., Brown N.L., Coulson A.R., Fiddes J.C.,
RA   Hutchison C.A. III, Slocombe P.M., Smith M.;
RT   "Nucleotide sequence of bacteriophage phi X174 DNA.";
RL   Nature 265:687-695(1977).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=731693; DOI=10.1016/0022-2836(78)90346-7;
RA   Sanger F., Coulson A.R., Friedmann T., Air G.M., Barrell B.G., Brown N.L.,
RA   Fiddes J.C., Hutchison C.A. III, Slocombe P.M., Smith M.;
RT   "The nucleotide sequence of bacteriophage phiX174.";
RL   J. Mol. Biol. 125:225-246(1978).
RN   [3]
RP   FUNCTION.
RX   PubMed=2944602; DOI=10.1016/0092-8674(86)90370-3;
RA   Aoyama A., Hayashi M.;
RT   "Synthesis of bacteriophage phi X174 in vitro: mechanism of switch from DNA
RT   replication to DNA packaging.";
RL   Cell 47:99-106(1986).
RN   [4]
RP   FUNCTION.
RX   PubMed=2972714; DOI=10.1016/s0021-9258(18)37613-0;
RA   Goetz G.S., Englard S., Schmidt-Glenewinkel T., Aoyama A., Hayashi M.,
RA   Hurwitz J.;
RT   "Effect of phi X C protein on leading strand DNA synthesis in the phi X174
RT   replication pathway.";
RL   J. Biol. Chem. 263:16452-16460(1988).
CC   -!- FUNCTION: Plays a central role in the packaging of viral DNA into phage
CC       procapsid, which occurs in the late stage of infection. The protein C
CC       can interact with the replicative complex composed of the protein A,
CC       the host rep and the viral DNA after the completion of one round of DNA
CC       synthesis. When protein C is bound to the replicative form, the complex
CC       becomes accessible to procapsid and serves as a DNA packaging
CC       apparatus. {ECO:0000269|PubMed:2944602, ECO:0000269|PubMed:2972714}.
CC   -!- SIMILARITY: Belongs to the microviridae C protein family.
CC       {ECO:0000305}.
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DR   EMBL; J02482; AAA32574.1; -; Genomic_DNA.
DR   PIR; A93185; ZCBPF4.
DR   SMR; P69172; -.
DR   Proteomes; UP000005893; Genome.
DR   GO; GO:0019073; P:viral DNA genome packaging; IEA:InterPro.
DR   InterPro; IPR016407; C-protein.
DR   Pfam; PF12025; Phage_C; 1.
DR   PIRSF; PIRSF004155; Phage_C; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..86
FT                   /note="Protein C"
FT                   /id="PRO_0000164875"
SQ   SEQUENCE   86 AA;  10081 MW;  28785348340CCE3C CRC64;
     MRKFDLSLRS SRSSYFATFR HQLTILSKTD ALDEEKWLNM LGTFVKDWFR YESHFVHGRD
     SLVDILKERG LLSESDAVQP LIGKKS