ID   C_PI1HC                 Reviewed;         204 AA.
AC   P28055;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   23-FEB-2022, entry version 44.
DE   RecName: Full=Protein C;
GN   Name=P/V/C;
OS   Human parainfluenza 1 virus (strain C39) (HPIV-1).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Respirovirus.
OX   NCBI_TaxID=11210;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1851888; DOI=10.1128/jvi.65.6.3406-3410.1991;
RA   Matsuoka Y., Curran J., Pelet T., Kolakofsky D., Ray R., Compans R.W.;
RT   "The P gene of human parainfluenza virus type 1 encodes P and C proteins
RT   but not a cysteine-rich V protein.";
RL   J. Virol. 65:3406-3410(1991).
CC   -!- SIMILARITY: Belongs to the respirovirus protein C family.
CC       {ECO:0000305}.
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DR   EMBL; M37792; AAA46869.1; -; mRNA.
DR   PIR; B39929; MNNZ39.
DR   SMR; P28055; -.
DR   GO; GO:0039563; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; ISS:UniProtKB.
DR   GO; GO:0039564; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002608; Paramyxo_C.
DR   Pfam; PF01692; Paramyxo_C; 1.
PE   2: Evidence at transcript level;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host STAT1 by virus; Inhibition of host STAT2 by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..204
FT                   /note="Protein C"
FT                   /id="PRO_0000142799"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   204 AA;  24111 MW;  6AACD91BD3430353 CRC64;
     MPSFLRGILK PKERHHENKN HSQVSSDSLT SSYPTSPPKL EKTEAGSMVS STTQKKTSHH
     AKPTITTKTE QSQRRPKIID QVRRVESLGE QVSQKQRHML DSLINKVYTG PLGEELVQTL
     YLRIWAMKET PESMKILQMR EDIRDQYLRM KTERWLRTLI RGKKTKLRDF QKRYEEVHPY
     LMMERVEQII MEEAWKLAAH IVQE