ID   C_PI1HE                 Reviewed;         204 AA.
AC   P32535;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   23-FEB-2022, entry version 46.
DE   RecName: Full=Protein C;
GN   Name=P/V/C;
OS   Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Respirovirus.
OX   NCBI_TaxID=31606;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1318610; DOI=10.1016/0042-6822(92)90712-x;
RA   Power U.F., Ryan K.W., Portner A.;
RT   "The P genes of human parainfluenza virus type 1 clinical isolates are
RT   polycistronic and microheterogeneous.";
RL   Virology 189:340-343(1992).
CC   -!- SIMILARITY: Belongs to the respirovirus protein C family.
CC       {ECO:0000305}.
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DR   EMBL; M74080; AAA46831.1; -; Genomic_RNA.
DR   PIR; F40234; MNNZ83.
DR   SMR; P32535; -.
DR   GO; GO:0039563; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; ISS:UniProtKB.
DR   GO; GO:0039564; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002608; Paramyxo_C.
DR   Pfam; PF01692; Paramyxo_C; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host STAT1 by virus; Inhibition of host STAT2 by virus;
KW   Viral immunoevasion.
FT   CHAIN           1..204
FT                   /note="Protein C"
FT                   /id="PRO_0000142801"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   204 AA;  24153 MW;  4DD691EC420EABA7 CRC64;
     MPSFLRGILR PKERHHENKN HSQMSSDSLT SSYPTSPPKL EKTEAGSIIS STTQKKTSHH
     ANLTITTKTE QSQRRPKIID QVRRVESLGE QVSQKQRHML ESLINKVYTG PLGEELVQTL
     YLRIWAMKET PESTKILQMR EDIRDQYLRM KTERWLRTLI RGKKTKLRDF QKRYEEVHPY
     LMMERVEQII MEEAWKLAAH IVQE