ID   D103A_GORGO             Reviewed;          67 AA.
AC   A4H1Z9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Beta-defensin 103A;
DE   AltName: Full=Defensin, beta 103;
DE   AltName: Full=Defensin, beta 103A;
DE   Flags: Precursor;
GN   Name=DEFB103A; Synonyms=DEFB103;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exhibits antimicrobial activity against Gram-positive and
CC       Gram-negative bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410104; CAL68919.1; -; Genomic_DNA.
DR   RefSeq; XP_004046650.1; XM_004046602.1.
DR   RefSeq; XP_018887588.1; XM_019032043.1.
DR   AlphaFoldDB; A4H1Z9; -.
DR   SMR; A4H1Z9; -.
DR   STRING; 9593.ENSGGOP00000006837; -.
DR   Ensembl; ENSGGOT00000058441; ENSGGOP00000036882; ENSGGOG00000039785.
DR   Ensembl; ENSGGOT00000061036; ENSGGOP00000040509; ENSGGOG00000039995.
DR   GeneID; 101125223; -.
DR   KEGG; ggo:101125223; -.
DR   eggNOG; ENOG502TF5P; Eukaryota.
DR   GeneTree; ENSGT00530000064280; -.
DR   HOGENOM; CLU_189296_2_0_1; -.
DR   InParanoid; A4H1Z9; -.
DR   OMA; EQIGHCS; -.
DR   OrthoDB; 1584343at2759; -.
DR   Proteomes; UP000001519; Chromosome 8.
DR   Bgee; ENSGGOG00000039785; Expressed in multicellular organism.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         23..67
FT                   /note="Beta-defensin 103A"
FT                   /id="PRO_0000289805"
FT   DISULFID        33..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..63
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   67 AA;  7727 MW;  542678F4C9185E65 CRC64;
     MRIHYLLFTL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLSCLPKEE QIGKCSTRGR
     KCCRRKK