ID   D103A_HORSE             Reviewed;          67 AA.
AC   Q0W9P9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Beta-defensin 103A;
DE   AltName: Full=Defensin, beta 103;
DE   AltName: Full=Defensin, beta 103A;
DE   Flags: Precursor;
GN   Name=DEFB103A; Synonyms=DEFB103;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16723195; DOI=10.1016/j.gene.2006.03.006;
RA   Looft C., Paul S., Philipp U., Regenhard P., Kuiper H., Distl O.,
RA   Chowdhary B.P., Leeb T.;
RT   "Sequence analysis of a 212 kb defensin gene cluster on ECA 27q17.";
RL   Gene 376:192-198(2006).
CC   -!- FUNCTION: Exhibits antimicrobial activity against Gram-positive and
CC       Gram-negative bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM039964; CAJ01801.1; -; Genomic_DNA.
DR   RefSeq; XP_003364293.1; XM_003364245.3.
DR   AlphaFoldDB; Q0W9P9; -.
DR   SMR; Q0W9P9; -.
DR   STRING; 9796.ENSECAP00000005162; -.
DR   PaxDb; Q0W9P9; -.
DR   Ensembl; ENSECAT00000007133; ENSECAP00000005162; ENSECAG00000007143.
DR   GeneID; 100629456; -.
DR   KEGG; ecb:100629456; -.
DR   GeneTree; ENSGT00530000064280; -.
DR   HOGENOM; CLU_189296_2_0_1; -.
DR   InParanoid; Q0W9P9; -.
DR   OMA; EQIGHCS; -.
DR   OrthoDB; 1630404at2759; -.
DR   Proteomes; UP000002281; Chromosome 27.
DR   Bgee; ENSECAG00000007143; Expressed in zone of skin and 5 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         23..67
FT                   /note="Beta-defensin 103A"
FT                   /id="PRO_0000289806"
FT   DISULFID        33..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..63
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   67 AA;  7545 MW;  8C327B78E71DD7B7 CRC64;
     MRIHFLLFAL LFLFLMPVPG NGGIINMLQK SYCKIRKGRC ALLGCLPKEE QIGSCSVSGR
     KCCRKKK