ID   D103A_PANTR             Reviewed;          67 AA.
AC   Q95JD2; A4H1Z8; Q30KM2; Q5IAC2;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Beta-defensin 103A;
DE   AltName: Full=Beta-defensin 3;
DE            Short=BD-3;
DE            Short=DEFB-3;
DE            Short=cBD-3;
DE   AltName: Full=Defensin, beta 103;
DE   AltName: Full=Defensin, beta 103A;
DE   Flags: Precursor;
GN   Name=DEFB103A; Synonyms=DEFB103, DEFB3;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-64.
RC   TISSUE=Skin;
RA   Duits L.A., Langermans J.A.M., Ravensbergen B., Paltansing S.,
RA   Vervenne R.A.W., Hiemstra P.S., Thomas A.W., Nibbering P.H.;
RT   "Expression of chimpanzee (Pan troglodytes) beta-defensin-3.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-67.
RX   PubMed=15904491; DOI=10.1186/1471-2148-5-32;
RA   Semple C.A.M., Maxwell A., Gautier P., Kilanowski F.M., Eastwood H.,
RA   Barran P.E., Dorin J.R.;
RT   "The complexity of selection at the major primate beta-defensin locus.";
RL   BMC Evol. Biol. 5:32-32(2005).
CC   -!- FUNCTION: Exhibits antimicrobial activity against Gram-positive and
CC       Gram-negative bacteria. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012056; AAY59788.1; -; mRNA.
DR   EMBL; AM410103; CAL68918.1; -; Genomic_DNA.
DR   EMBL; AY033883; AAK61549.1; -; mRNA.
DR   EMBL; AY831729; AAW32910.1; -; Genomic_DNA.
DR   RefSeq; NP_001123222.1; NM_001129750.1.
DR   AlphaFoldDB; Q95JD2; -.
DR   SMR; Q95JD2; -.
DR   STRING; 9598.ENSPTRP00000034200; -.
DR   PaxDb; Q95JD2; -.
DR   Ensembl; ENSPTRT00000037006; ENSPTRP00000034200; ENSPTRG00000019964.
DR   GeneID; 450106; -.
DR   KEGG; ptr:450106; -.
DR   CTD; 414325; -.
DR   eggNOG; ENOG502TF5P; Eukaryota.
DR   GeneTree; ENSGT00530000064280; -.
DR   HOGENOM; CLU_189296_2_0_1; -.
DR   InParanoid; Q95JD2; -.
DR   OMA; EQIGHCS; -.
DR   OrthoDB; 1630404at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   Bgee; ENSPTRG00000019964; Expressed in fibroblast and 2 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR   GO; GO:0051873; P:killing by host of symbiont cells; IEA:Ensembl.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:Ensembl.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         23..67
FT                   /note="Beta-defensin 103A"
FT                   /id="PRO_0000006972"
FT   DISULFID        33..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..63
FT                   /evidence="ECO:0000250"
FT   CONFLICT        60
FT                   /note="R -> Q (in Ref. 2; CAL68918)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   67 AA;  7711 MW;  54516DE1C90D4B60 CRC64;
     MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLTCLPKEE QIGKCSTRGR
     KCCRRKK