D103A_PONPY
ID D103A_PONPY Reviewed; 67 AA.
AC A4H200;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Beta-defensin 103A;
DE AltName: Full=Defensin, beta 103;
DE AltName: Full=Defensin, beta 103A;
DE Flags: Precursor;
GN Name=DEFB103A; Synonyms=DEFB103;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hollox E.J., Armour J.A.L.;
RT "Evolution and sequence variation of human beta-defensin genes.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Exhibits antimicrobial activity against Gram-positive and
CC Gram-negative bacteria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AM410105; CAL68920.1; -; Genomic_DNA.
DR AlphaFoldDB; A4H200; -.
DR SMR; A4H200; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT PEPTIDE 23..67
FT /note="Beta-defensin 103A"
FT /id="PRO_0000289807"
FT DISULFID 33..62
FT /evidence="ECO:0000250"
FT DISULFID 40..55
FT /evidence="ECO:0000250"
FT DISULFID 45..63
FT /evidence="ECO:0000250"
SQ SEQUENCE 67 AA; 7697 MW; 54266DE1C90D4B65 CRC64;
MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLSCLPKEE QIGKCSTRGR
KCCRRKK