D104A_GORGO
ID D104A_GORGO Reviewed; 72 AA.
AC A4H202;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Beta-defensin 104A;
DE AltName: Full=Defensin, beta 104;
DE AltName: Full=Defensin, beta 104A;
DE Flags: Precursor;
GN Name=DEFB104A; Synonyms=DEFB104;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hollox E.J., Armour J.A.L.;
RT "Evolution and sequence variation of human beta-defensin genes.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has antimicrobial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AM410107; CAL68922.1; -; Genomic_DNA.
DR AlphaFoldDB; A4H202; -.
DR SMR; A4H202; -.
DR PRIDE; A4H202; -.
DR eggNOG; ENOG502TDUP; Eukaryota.
DR HOGENOM; CLU_202010_0_0_1; -.
DR InParanoid; A4H202; -.
DR Proteomes; UP000001519; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PEPTIDE 23..72
FT /note="Beta-defensin 104A"
FT /id="PRO_0000289808"
FT DISULFID 30..57
FT /evidence="ECO:0000250"
FT DISULFID 37..51
FT /evidence="ECO:0000250"
FT DISULFID 41..58
FT /evidence="ECO:0000250"
SQ SEQUENCE 72 AA; 8538 MW; 464E947AF2FF8F2C CRC64;
MRRLVLLLAI SLLLYQDLPV RSEFELDRIC GYGTARCRKK CRSQEYRIGR CPNTFACCLR
KWDESLLNRT KP