ID   D105A_GORGO             Reviewed;          78 AA.
AC   A4H206;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Beta-defensin 105A;
DE   AltName: Full=Defensin, beta 105;
DE   AltName: Full=Defensin, beta 105A;
DE   Flags: Precursor;
GN   Name=DEFB105A; Synonyms=DEFB105;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410111; CAL68926.1; -; Genomic_DNA.
DR   RefSeq; XP_004046656.1; XM_004046608.1.
DR   AlphaFoldDB; A4H206; -.
DR   SMR; A4H206; -.
DR   STRING; 9593.ENSGGOP00000006867; -.
DR   Ensembl; ENSGGOT00000007048; ENSGGOP00000006867; ENSGGOG00000007021.
DR   GeneID; 101127763; -.
DR   KEGG; ggo:101127763; -.
DR   eggNOG; ENOG502TE24; Eukaryota.
DR   GeneTree; ENSGT00390000002317; -.
DR   HOGENOM; CLU_197691_0_0_1; -.
DR   InParanoid; A4H206; -.
DR   OMA; CQAGLEF; -.
DR   OrthoDB; 1579011at2759; -.
DR   Proteomes; UP000001519; Chromosome 8.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         28..78
FT                   /note="Beta-defensin 105A"
FT                   /id="PRO_0000289811"
FT   DISULFID        43..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8890 MW;  B4F42B15E3A41A05 CRC64;
     MALIRKTFYF LFAVFFILVQ LPSGCQAGLD FSQPFPSGEF AVCESCKLGR GKCRKECLEN
     EKPDGNCRLN FLCCRQRI