D105A_HUMAN
ID D105A_HUMAN Reviewed; 78 AA.
AC Q8NG35; A1A581; Q8IZN8;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Beta-defensin 105;
DE AltName: Full=Beta-defensin 5;
DE Short=BD-5;
DE Short=DEFB-5;
DE AltName: Full=Defensin, beta 105;
DE Flags: Precursor;
GN Name=DEFB105A; Synonyms=BD5, DEFB105, DEFB5;
GN and
GN Name=DEFB105B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epididymis;
RX PubMed=12193721; DOI=10.4049/jimmunol.169.5.2516;
RA Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T.,
RA Kurihara H., Ouchi Y.;
RT "Identification of multiple novel epididymis-specific beta-defensin
RT isoforms in humans and mice.";
RL J. Immunol. 169:2516-2523(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-77.
RX PubMed=12734011; DOI=10.1186/gb-2003-4-5-r31;
RA Semple C.A.M., Rolfe M., Dorin J.R.;
RT "Duplication and selection in the evolution of primate beta-defensin
RT genes.";
RL Genome Biol. 4:R31.1-R31.11(2003).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AB089180; BAC10630.1; -; mRNA.
DR EMBL; BC128437; AAI28438.1; -; mRNA.
DR EMBL; BC128438; AAI28439.1; -; mRNA.
DR EMBL; AF540977; AAN33113.1; -; mRNA.
DR CCDS; CCDS34814.1; -.
DR CCDS; CCDS34832.1; -.
DR RefSeq; NP_001035793.1; NM_001040703.2.
DR RefSeq; NP_689463.1; NM_152250.2.
DR AlphaFoldDB; Q8NG35; -.
DR SMR; Q8NG35; -.
DR BioGRID; 128833; 1.
DR BioGRID; 139060; 182.
DR STRING; 9606.ENSP00000334330; -.
DR BioMuta; DEFB105A; -.
DR DMDM; 37077353; -.
DR MassIVE; Q8NG35; -.
DR PaxDb; Q8NG35; -.
DR PeptideAtlas; Q8NG35; -.
DR PRIDE; Q8NG35; -.
DR ProteomicsDB; 73417; -.
DR Antibodypedia; 56705; 4 antibodies from 3 providers.
DR Antibodypedia; 68998; 13 antibodies from 4 providers.
DR DNASU; 245908; -.
DR Ensembl; ENST00000334773.7; ENSP00000334330.6; ENSG00000186562.8.
DR Ensembl; ENST00000335510.7; ENSP00000335281.6; ENSG00000186599.8.
DR Ensembl; ENST00000611610.1; ENSP00000482176.1; ENSG00000274729.1.
DR Ensembl; ENST00000644948.2; ENSP00000496561.1; ENSG00000285015.2.
DR GeneID; 245908; -.
DR GeneID; 504180; -.
DR KEGG; hsa:245908; -.
DR KEGG; hsa:504180; -.
DR MANE-Select; ENST00000334773.7; ENSP00000334330.6; NM_152250.3; NP_689463.1.
DR MANE-Select; ENST00000335510.7; ENSP00000335281.6; NM_001040703.3; NP_001035793.1.
DR UCSC; uc011kwp.3; human.
DR CTD; 245908; -.
DR CTD; 504180; -.
DR GeneCards; DEFB105A; -.
DR GeneCards; DEFB105B; -.
DR HGNC; HGNC:18087; DEFB105A.
DR HGNC; HGNC:29930; DEFB105B.
DR HPA; ENSG00000186562; Not detected.
DR HPA; ENSG00000186599; Tissue enriched (epididymis).
DR neXtProt; NX_Q8NG35; -.
DR OpenTargets; ENSG00000186599; -.
DR PharmGKB; PA142671991; -.
DR VEuPathDB; HostDB:ENSG00000186562; -.
DR VEuPathDB; HostDB:ENSG00000186599; -.
DR eggNOG; ENOG502TE24; Eukaryota.
DR GeneTree; ENSGT00390000002317; -.
DR HOGENOM; CLU_197691_0_0_1; -.
DR InParanoid; Q8NG35; -.
DR OMA; CQAGLEF; -.
DR OrthoDB; 1579011at2759; -.
DR PhylomeDB; Q8NG35; -.
DR PathwayCommons; Q8NG35; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR BioGRID-ORCS; 245908; 11 hits in 908 CRISPR screens.
DR BioGRID-ORCS; 504180; 10 hits in 614 CRISPR screens.
DR GeneWiki; DEFB105A; -.
DR Pharos; Q8NG35; Tbio.
DR PRO; PR:Q8NG35; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8NG35; protein.
DR Bgee; ENSG00000186562; Expressed in muscle tissue and 32 other tissues.
DR ExpressionAtlas; Q8NG35; baseline.
DR Genevisible; Q8NG35; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PEPTIDE 28..78
FT /note="Beta-defensin 105"
FT /id="PRO_0000006975"
FT DISULFID 43..74
FT /evidence="ECO:0000250"
FT DISULFID 53..67
FT /evidence="ECO:0000250"
FT DISULFID 57..73
FT /evidence="ECO:0000250"
SQ SEQUENCE 78 AA; 8923 MW; A0B07B01A7F41A05 CRC64;
MALIRKTFYF LFAMFFILVQ LPSGCQAGLD FSQPFPSGEF AVCESCKLGR GKCRKECLEN
EKPDGNCRLN FLCCRQRI
