ID   D105A_PANTR             Reviewed;          78 AA.
AC   Q5IAB6; A4H205; Q30KM0;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Beta-defensin 105A;
DE   AltName: Full=Beta-defensin 5;
DE            Short=BD-5;
DE            Short=DEFB-5;
DE            Short=cBD-5;
DE   AltName: Full=Defensin, beta 105;
DE   AltName: Full=Defensin, beta 105A;
DE   Flags: Precursor;
GN   Name=DEFB105A; Synonyms=DEFB105, DEFB5;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-77.
RX   PubMed=15904491; DOI=10.1186/1471-2148-5-32;
RA   Semple C.A.M., Maxwell A., Gautier P., Kilanowski F.M., Eastwood H.,
RA   Barran P.E., Dorin J.R.;
RT   "The complexity of selection at the major primate beta-defensin locus.";
RL   BMC Evol. Biol. 5:32-32(2005).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012058; AAY59790.1; -; mRNA.
DR   EMBL; AM410110; CAL68925.1; -; Genomic_DNA.
DR   EMBL; AY831735; AAW32916.1; -; Genomic_DNA.
DR   RefSeq; NP_001123225.1; NM_001129753.1.
DR   AlphaFoldDB; Q5IAB6; -.
DR   SMR; Q5IAB6; -.
DR   STRING; 9598.ENSPTRP00000034193; -.
DR   PaxDb; Q5IAB6; -.
DR   Ensembl; ENSPTRT00000036999; ENSPTRP00000034193; ENSPTRG00000019960.
DR   GeneID; 736034; -.
DR   KEGG; ptr:736034; -.
DR   CTD; 245908; -.
DR   eggNOG; ENOG502TE24; Eukaryota.
DR   GeneTree; ENSGT00390000002317; -.
DR   HOGENOM; CLU_197691_0_0_1; -.
DR   InParanoid; Q5IAB6; -.
DR   OMA; CQAGLEF; -.
DR   OrthoDB; 1579011at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   Bgee; ENSPTRG00000019960; Expressed in prefrontal cortex.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         28..78
FT                   /note="Beta-defensin 105A"
FT                   /id="PRO_0000006976"
FT   DISULFID        43..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8868 MW;  BB17FA3FBBC4A595 CRC64;
     MALIKKTFFF LFAMFFILVQ LSSGCQAGLD FSQPFPSGEF AVCESCKLGR GKCRKECLEN
     EKPDGNCRLN FLCCRQRI