ID   D105B_MACFA             Reviewed;          78 AA.
AC   A4H209;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Beta-defensin 105A;
DE   AltName: Full=Defensin, beta 105;
DE   AltName: Full=Defensin, beta 105A;
DE   Flags: Precursor;
GN   Name=DEFB105A; Synonyms=DEFB105;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM410114; CAL68929.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4H209; -.
DR   SMR; A4H209; -.
DR   STRING; 9541.XP_005562613.1; -.
DR   PRIDE; A4H209; -.
DR   Ensembl; ENSMFAT00000065448; ENSMFAP00000014934; ENSMFAG00000030679.
DR   Ensembl; ENSMFAT00000077180; ENSMFAP00000048802; ENSMFAG00000030679.
DR   Ensembl; ENSMFAT00000080832; ENSMFAP00000047906; ENSMFAG00000030679.
DR   Ensembl; ENSMFAT00000089616; ENSMFAP00000056580; ENSMFAG00000030679.
DR   Ensembl; ENSMFAT00000101217; ENSMFAP00000051471; ENSMFAG00000056365.
DR   VEuPathDB; HostDB:ENSMFAG00000030679; -.
DR   eggNOG; ENOG502TE24; Eukaryota.
DR   GeneTree; ENSGT00390000002317; -.
DR   OMA; CQAGLEF; -.
DR   Proteomes; UP000233100; Chromosome 8.
DR   Bgee; ENSMFAG00000030679; Expressed in multicellular organism.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         28..78
FT                   /note="Beta-defensin 105A"
FT                   /id="PRO_0000289813"
FT   DISULFID        43..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8894 MW;  B5A5D7DC61605EAB CRC64;
     MALIRKTFYF VFAVFFILVQ QPSGCQAGLE FSEPFPSGRF AVCESCKLGR GKCRKECLEN
     EKPDGSCRLN FLCCRPRM