ID   D106A_GORGO             Reviewed;          65 AA.
AC   A4H211;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Beta-defensin 106A;
DE   AltName: Full=Defensin, beta 106;
DE   AltName: Full=Defensin, beta 106A;
DE   Flags: Precursor;
GN   Name=DEFB106A; Synonyms=DEFB106;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. Acts as a ligand for C-C
CC       chemokine receptor CCR2. {ECO:0000250|UniProtKB:Q8N104}.
CC   -!- SUBUNIT: Monomer. Interacts with CCR2 (via extracellular N-terminal
CC       region); this interaction may preferentially require specific tyrosine
CC       sulfation on CCR2. {ECO:0000250|UniProtKB:Q8N104}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8N104}. Membrane
CC       {ECO:0000250|UniProtKB:Q8N104}. Note=Associates with tumor cell
CC       membrane-derived microvesicles. {ECO:0000250|UniProtKB:Q8N104}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410116; CAL68931.1; -; Genomic_DNA.
DR   RefSeq; XP_004046657.1; XM_004046609.2.
DR   AlphaFoldDB; A4H211; -.
DR   SMR; A4H211; -.
DR   STRING; 9593.ENSGGOP00000003580; -.
DR   Ensembl; ENSGGOT00000003660; ENSGGOP00000003580; ENSGGOG00000003644.
DR   GeneID; 101128133; -.
DR   KEGG; ggo:101128133; -.
DR   eggNOG; ENOG502TF62; Eukaryota.
DR   GeneTree; ENSGT00390000005938; -.
DR   HOGENOM; CLU_187814_0_0_1; -.
DR   InParanoid; A4H211; -.
DR   OMA; RGTCKNN; -.
DR   OrthoDB; 1629258at2759; -.
DR   Proteomes; UP000001519; Chromosome 8.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250|UniProtKB:Q8N104"
FT   PEPTIDE         21..65
FT                   /note="Beta-defensin 106A"
FT                   /id="PRO_0000289815"
FT   DISULFID        26..53
FT                   /evidence="ECO:0000250|UniProtKB:Q8N104"
FT   DISULFID        33..47
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   65 AA;  7369 MW;  9D1C89BB0041E02D CRC64;
     MRTFLFLFAV LFFLTPAKNA FFDEKCNKLK GTCKNNCGKN EELIALCQKS LKCCRTIQPC
     GSIID