D106A_PANTR
ID D106A_PANTR Reviewed; 65 AA.
AC Q5IAB3; A4H210; Q30KL9;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Beta-defensin 106A;
DE AltName: Full=Beta-defensin 6;
DE Short=BD-6;
DE Short=DEFB-6;
DE Short=cBD-6;
DE AltName: Full=Defensin, beta 106;
DE AltName: Full=Defensin, beta 106A;
DE Flags: Precursor;
GN Name=DEFB106A; Synonyms=DEFB106, DEFB6;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hollox E.J., Armour J.A.L.;
RT "Evolution and sequence variation of human beta-defensin genes.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-65.
RX PubMed=15904491; DOI=10.1186/1471-2148-5-32;
RA Semple C.A.M., Maxwell A., Gautier P., Kilanowski F.M., Eastwood H.,
RA Barran P.E., Dorin J.R.;
RT "The complexity of selection at the major primate beta-defensin locus.";
RL BMC Evol. Biol. 5:32-32(2005).
CC -!- FUNCTION: Has antibacterial activity. Acts as a ligand for C-C
CC chemokine receptor CCR2. {ECO:0000250|UniProtKB:Q8N104}.
CC -!- SUBUNIT: Monomer. Interacts with CCR2 (via extracellular N-terminal
CC region); this interaction may preferentially require specific tyrosine
CC sulfation on CCR2. {ECO:0000250|UniProtKB:Q8N104}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8N104}. Membrane
CC {ECO:0000250|UniProtKB:Q8N104}. Note=Associates with tumor cell
CC membrane-derived microvesicles. {ECO:0000250|UniProtKB:Q8N104}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; DQ012059; AAY59791.1; -; mRNA.
DR EMBL; AM410115; CAL68930.1; -; Genomic_DNA.
DR EMBL; AY831738; AAW32919.1; -; Genomic_DNA.
DR RefSeq; NP_001123228.1; NM_001129756.1.
DR AlphaFoldDB; Q5IAB3; -.
DR SMR; Q5IAB3; -.
DR STRING; 9598.ENSPTRP00000034194; -.
DR PaxDb; Q5IAB3; -.
DR Ensembl; ENSPTRT00000037000; ENSPTRP00000034194; ENSPTRG00000019961.
DR GeneID; 735983; -.
DR KEGG; ptr:735983; -.
DR CTD; 245909; -.
DR eggNOG; ENOG502TF62; Eukaryota.
DR GeneTree; ENSGT00390000005938; -.
DR HOGENOM; CLU_187814_0_0_1; -.
DR InParanoid; Q5IAB3; -.
DR OMA; RGTCKNN; -.
DR OrthoDB; 1629258at2759; -.
DR Proteomes; UP000002277; Unplaced.
DR Bgee; ENSPTRG00000019961; Expressed in prefrontal cortex and 1 other tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250|UniProtKB:Q8N104"
FT PEPTIDE 21..65
FT /note="Beta-defensin 106A"
FT /id="PRO_0000006978"
FT DISULFID 26..53
FT /evidence="ECO:0000250|UniProtKB:Q8N104"
FT DISULFID 33..47
FT /evidence="ECO:0000250"
FT DISULFID 37..54
FT /evidence="ECO:0000250"
SQ SEQUENCE 65 AA; 7369 MW; 9D1C89BB0041E02D CRC64;
MRTFLFLFAV LFFLTPAKNA FFDEKCNKLK GTCKNNCGKN EELIALCQKS LKCCRTIQPC
GSIID
