D107A_HUMAN
ID D107A_HUMAN Reviewed; 70 AA.
AC Q8IZN7; B2RPM1; Q30E75; Q8NET2;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 3.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Beta-defensin 107;
DE AltName: Full=Beta-defensin 7;
DE Short=BD-7;
DE Short=DEFB-7;
DE AltName: Full=Defensin, beta 107;
DE Flags: Precursor;
GN Name=DEFB107A; Synonyms=DEFB107, DEFB7;
GN and
GN Name=DEFB107B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-67.
RX PubMed=12734011; DOI=10.1186/gb-2003-4-5-r31;
RA Semple C.A.M., Rolfe M., Dorin J.R.;
RT "Duplication and selection in the evolution of primate beta-defensin
RT genes.";
RL Genome Biol. 4:R31.1-R31.11(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-64.
RC TISSUE=Testis;
RX PubMed=11854508; DOI=10.1073/pnas.042692699;
RA Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT "Discovery of five conserved beta-defensin gene clusters using a
RT computational search strategy.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAZ81951.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; DQ119826; AAZ81951.1; ALT_INIT; mRNA.
DR EMBL; AC134684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137510; AAI37511.1; -; mRNA.
DR EMBL; BC137513; AAI37514.1; -; mRNA.
DR EMBL; AF540979; AAN33115.1; -; mRNA.
DR EMBL; AY122467; AAM93909.1; -; mRNA.
DR CCDS; CCDS43696.1; -.
DR CCDS; CCDS43699.1; -.
DR RefSeq; NP_001032757.2; NM_001037668.1.
DR RefSeq; NP_001035795.1; NM_001040705.1.
DR AlphaFoldDB; Q8IZN7; -.
DR BioGRID; 128835; 12.
DR BioGRID; 139020; 2.
DR STRING; 9606.ENSP00000334681; -.
DR BioMuta; DEFB107A; -.
DR DMDM; 226694192; -.
DR PaxDb; Q8IZN7; -.
DR PRIDE; Q8IZN7; -.
DR Antibodypedia; 66838; 32 antibodies from 11 providers.
DR Antibodypedia; 76576; 2 antibodies from 2 providers.
DR DNASU; 503614; -.
DR Ensembl; ENST00000335021.2; ENSP00000334681.2; ENSG00000186572.2.
DR Ensembl; ENST00000355602.3; ENSP00000347810.2; ENSG00000198129.3.
DR Ensembl; ENST00000615431.1; ENSP00000478422.1; ENSG00000277530.1.
DR Ensembl; ENST00000642785.1; ENSP00000495534.1; ENSG00000285432.1.
DR Ensembl; ENST00000646983.2; ENSP00000493774.1; ENSG00000284979.2.
DR GeneID; 245910; -.
DR GeneID; 503614; -.
DR KEGG; hsa:245910; -.
DR KEGG; hsa:503614; -.
DR MANE-Select; ENST00000335021.2; ENSP00000334681.2; NM_001037668.1; NP_001032757.2.
DR MANE-Select; ENST00000355602.3; ENSP00000347810.2; NM_001040705.2; NP_001035795.1.
DR UCSC; uc003wrq.1; human.
DR CTD; 245910; -.
DR CTD; 503614; -.
DR DisGeNET; 245910; -.
DR DisGeNET; 503614; -.
DR GeneCards; DEFB107A; -.
DR GeneCards; DEFB107B; -.
DR HGNC; HGNC:18086; DEFB107A.
DR HGNC; HGNC:31918; DEFB107B.
DR HPA; ENSG00000186572; Tissue enriched (epididymis).
DR HPA; ENSG00000198129; Tissue enriched (epididymis).
DR neXtProt; NX_Q8IZN7; -.
DR OpenTargets; ENSG00000186572; -.
DR PharmGKB; PA142671993; -.
DR VEuPathDB; HostDB:ENSG00000186572; -.
DR VEuPathDB; HostDB:ENSG00000198129; -.
DR eggNOG; ENOG502TF47; Eukaryota.
DR GeneTree; ENSGT00390000013953; -.
DR HOGENOM; CLU_2757177_0_0_1; -.
DR InParanoid; Q8IZN7; -.
DR OMA; CEVECLS; -.
DR OrthoDB; 1617545at2759; -.
DR PhylomeDB; Q8IZN7; -.
DR PathwayCommons; Q8IZN7; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR BioGRID-ORCS; 245910; 8 hits in 172 CRISPR screens.
DR BioGRID-ORCS; 503614; 6 hits in 865 CRISPR screens.
DR Pharos; Q8IZN7; Tdark.
DR PRO; PR:Q8IZN7; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8IZN7; protein.
DR Bgee; ENSG00000186572; Expressed in cell and 24 other tissues.
DR Genevisible; Q8IZN7; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IMP:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PEPTIDE 27..70
FT /note="Beta-defensin 107"
FT /id="PRO_0000006979"
FT DISULFID 41..55
FT /evidence="ECO:0000250"
FT DISULFID 45..64
FT /evidence="ECO:0000250"
FT CONFLICT 9
FT /note="V -> F (in Ref. 5; AAM93909)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 70 AA; 7846 MW; 5A68683397E7ACCB CRC64;
MPGAMKIFVF ILAALILLAQ IFQARTAIHR ALISKRMEGH CEAECLTFEV KIGGCRAELA
PFCCKNRKKH
