D107A_PANTR
ID D107A_PANTR Reviewed; 70 AA.
AC Q5IAA9; A4H214; Q30KL8;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 3.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Beta-defensin 107A;
DE AltName: Full=Beta-defensin 7;
DE Short=BD-7;
DE Short=DEFB-7;
DE Short=cBD-7;
DE AltName: Full=Defensin, beta 107;
DE AltName: Full=Defensin, beta 107A;
DE Flags: Precursor;
GN Name=DEFB107A; Synonyms=DEFB107, DEFB7;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-70.
RA Hollox E.J., Armour J.A.L.;
RT "Evolution and sequence variation of human beta-defensin genes.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-67.
RX PubMed=15904491; DOI=10.1186/1471-2148-5-32;
RA Semple C.A.M., Maxwell A., Gautier P., Kilanowski F.M., Eastwood H.,
RA Barran P.E., Dorin J.R.;
RT "The complexity of selection at the major primate beta-defensin locus.";
RL BMC Evol. Biol. 5:32-32(2005).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
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DR EMBL; DQ012060; AAY59792.1; -; mRNA.
DR EMBL; AM410119; CAL68934.1; -; Genomic_DNA.
DR EMBL; AY831742; AAW32923.1; -; Genomic_DNA.
DR RefSeq; NP_001123229.1; NM_001129757.1.
DR AlphaFoldDB; Q5IAA9; -.
DR STRING; 9598.ENSPTRP00000055816; -.
DR PaxDb; Q5IAA9; -.
DR Ensembl; ENSPTRT00000036997; ENSPTRP00000034191; ENSPTRG00000019959.
DR GeneID; 100170022; -.
DR KEGG; ptr:100170022; -.
DR CTD; 245910; -.
DR eggNOG; ENOG502TF47; Eukaryota.
DR GeneTree; ENSGT00390000013953; -.
DR HOGENOM; CLU_2757177_0_0_1; -.
DR InParanoid; Q5IAA9; -.
DR OMA; CEVECLS; -.
DR OrthoDB; 1617545at2759; -.
DR Proteomes; UP000002277; Unplaced.
DR Bgee; ENSPTRG00000019959; Expressed in prefrontal cortex and 1 other tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PEPTIDE 27..70
FT /note="Beta-defensin 107A"
FT /id="PRO_0000006980"
FT DISULFID 41..55
FT /evidence="ECO:0000250"
FT DISULFID 45..64
FT /evidence="ECO:0000250"
FT CONFLICT 24..26
FT /note="Missing (in Ref. 3; AAW32923)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 70 AA; 7916 MW; 417377E3A7FDB6CB CRC64;
MPGAMKIFFF IFAALILLAQ IFQARTAIHR ALISKRMEGH CEAECLTFEV KTGGCRAELA
PFCCKNRKKH