ID   D107A_PONPY             Reviewed;          66 AA.
AC   A4H216;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Beta-defensin 107A;
DE   AltName: Full=Defensin, beta 107;
DE   AltName: Full=Defensin, beta 107A;
DE   Flags: Precursor;
GN   Name=DEFB107A; Synonyms=DEFB107;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hollox E.J., Armour J.A.L.;
RT   "Evolution and sequence variation of human beta-defensin genes.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AM410121; CAL68936.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4H216; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..66
FT                   /note="Beta-defensin 107A"
FT                   /id="PRO_0000289821"
FT   DISULFID        37..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   66 AA;  7587 MW;  4005368C32203E84 CRC64;
     MKIFFFIFAA LILLAQIFQA RTAIHRALIC KRMEGHCEAE CLTFEVKIGG CRAELAPFCC
     KNRKKH