D108B_HUMAN
ID D108B_HUMAN Reviewed; 73 AA.
AC Q8NET1;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2003, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Beta-defensin 108B;
DE AltName: Full=Beta-defensin 8;
DE Short=BD-8;
DE Short=DEFB-8;
DE Short=hBD-8;
DE AltName: Full=Defensin, beta 108;
DE AltName: Full=Defensin, beta 108B;
DE Flags: Precursor;
GN Name=DEFB108B; Synonyms=DEFB108, DEFB8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12600824; DOI=10.1165/rcmb.2002-0205oc;
RA Kao C.Y., Chen Y., Zhao Y.H., Wu R.;
RT "ORFeome-based search of airway epithelial cell-specific novel human beta-
RT defensin genes.";
RL Am. J. Respir. Cell Mol. Biol. 29:71-80(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 22-73, AND IDENTIFICATION.
RC TISSUE=Testis;
RX PubMed=11854508; DOI=10.1073/pnas.042692699;
RA Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT "Discovery of five conserved beta-defensin gene clusters using a
RT computational search strategy.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-59, AND VARIANT ARG-53.
RX PubMed=12734011; DOI=10.1186/gb-2003-4-5-r31;
RA Semple C.A.M., Rolfe M., Dorin J.R.;
RT "Duplication and selection in the evolution of primate beta-defensin
RT genes.";
RL Genome Biol. 4:R31.1-R31.11(2003).
CC -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8NET1; Q13520: AQP6; NbExp=3; IntAct=EBI-13346443, EBI-13059134;
CC Q8NET1; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-13346443, EBI-13345167;
CC Q8NET1; Q9UKG4: SLC13A4; NbExp=3; IntAct=EBI-13346443, EBI-12808018;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis. Low expression is
CC detected also in liver. {ECO:0000269|PubMed:12600824}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AF529416; AAQ09525.1; -; mRNA.
DR EMBL; AY122468; AAM93910.1; -; mRNA.
DR EMBL; AF540980; AAN33116.1; -; mRNA.
DR CCDS; CCDS31631.1; -.
DR RefSeq; NP_001002035.1; NM_001002035.1.
DR AlphaFoldDB; Q8NET1; -.
DR SMR; Q8NET1; -.
DR BioGRID; 128836; 3.
DR IntAct; Q8NET1; 3.
DR STRING; 9606.ENSP00000333234; -.
DR BioMuta; DEFB108B; -.
DR DMDM; 37154739; -.
DR PaxDb; Q8NET1; -.
DR PRIDE; Q8NET1; -.
DR Antibodypedia; 49119; 16 antibodies from 8 providers.
DR DNASU; 245911; -.
DR Ensembl; ENST00000328698.2; ENSP00000333234.1; ENSG00000184276.3.
DR GeneID; 245911; -.
DR KEGG; hsa:245911; -.
DR MANE-Select; ENST00000328698.2; ENSP00000333234.1; NM_001002035.2; NP_001002035.1.
DR UCSC; uc010rqr.2; human.
DR CTD; 245911; -.
DR DisGeNET; 245911; -.
DR GeneCards; DEFB108B; -.
DR HGNC; HGNC:29966; DEFB108B.
DR HPA; ENSG00000184276; Tissue enriched (epididymis).
DR neXtProt; NX_Q8NET1; -.
DR OpenTargets; ENSG00000184276; -.
DR PharmGKB; PA142671994; -.
DR VEuPathDB; HostDB:ENSG00000184276; -.
DR eggNOG; ENOG502T9UC; Eukaryota.
DR GeneTree; ENSGT00390000009472; -.
DR HOGENOM; CLU_196184_0_0_1; -.
DR InParanoid; Q8NET1; -.
DR OMA; FCLDSEI; -.
DR OrthoDB; 1541504at2759; -.
DR PhylomeDB; Q8NET1; -.
DR PathwayCommons; Q8NET1; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR SignaLink; Q8NET1; -.
DR BioGRID-ORCS; 245911; 17 hits in 989 CRISPR screens.
DR GenomeRNAi; 245911; -.
DR Pharos; Q8NET1; Tdark.
DR PRO; PR:Q8NET1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NET1; protein.
DR Bgee; ENSG00000184276; Expressed in corpus callosum and 65 other tissues.
DR Genevisible; Q8NET1; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PEPTIDE 23..73
FT /note="Beta-defensin 108B"
FT /id="PRO_0000006981"
FT DISULFID 28..55
FT /evidence="ECO:0000250"
FT DISULFID 35..49
FT /evidence="ECO:0000250"
FT DISULFID 39..56
FT /evidence="ECO:0000250"
FT VARIANT 27
FT /note="I -> V (in dbSNP:rs12285436)"
FT /id="VAR_059246"
FT VARIANT 36
FT /note="R -> W (in dbSNP:rs12793731)"
FT /id="VAR_048862"
FT VARIANT 45
FT /note="H -> L (in dbSNP:rs12285495)"
FT /id="VAR_059247"
FT VARIANT 53
FT /note="Q -> R (in dbSNP:rs7120658)"
FT /evidence="ECO:0000269|PubMed:12734011"
FT /id="VAR_059248"
FT CONFLICT 7..9
FT /note="LFA -> FFT (in Ref. 3; AAN33116)"
FT /evidence="ECO:0000305"
FT CONFLICT 21
FT /note="R -> K (in Ref. 3; AAN33116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 73 AA; 8326 MW; 6820F297B7C2B7F2 CRC64;
MRIAVLLFAI FFFMSQVLPA RGKFKEICER PNGSCRDFCL ETEIHVGRCL NSQPCCLPLG
HQPRIESTTP KKD
