ID   D108B_PANTR             Reviewed;          53 AA.
AC   Q5IAA6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Beta-defensin 108B;
DE   AltName: Full=Beta-defensin 8;
DE            Short=BD-8;
DE            Short=DEFB-8;
DE            Short=cBD-8;
DE   AltName: Full=Defensin, beta 108;
DE   AltName: Full=Defensin, beta 108B;
DE   Flags: Precursor; Fragment;
GN   Name=DEFB108B; Synonyms=DEFB108, DEFB8;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15904491; DOI=10.1186/1471-2148-5-32;
RA   Semple C.A.M., Maxwell A., Gautier P., Kilanowski F.M., Eastwood H.,
RA   Barran P.E., Dorin J.R.;
RT   "The complexity of selection at the major primate beta-defensin locus.";
RL   BMC Evol. Biol. 5:32-32(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY831745; AAW32926.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5IAA6; -.
DR   SMR; Q5IAA6; -.
DR   STRING; 9598.ENSPTRP00000006911; -.
DR   PaxDb; Q5IAA6; -.
DR   eggNOG; ENOG502T9UC; Eukaryota.
DR   InParanoid; Q5IAA6; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          <1..2
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         3..53
FT                   /note="Beta-defensin 108B"
FT                   /id="PRO_0000006982"
FT   DISULFID        8..35
FT                   /evidence="ECO:0000250"
FT   DISULFID        15..29
FT                   /evidence="ECO:0000250"
FT   DISULFID        19..36
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   53 AA;  6058 MW;  11C7DFE35605D9D4 CRC64;
     RGKFKEICER PDGSCRDFCL ETEIHVGRCL NSRPCCLPLG HQPRIESTTP KKD