D11_DICDI
ID D11_DICDI Reviewed; 284 AA.
AC P05817; Q553H2; Q8T1D1;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 3.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Prestalk D11 protein;
DE AltName: Full=Adhesion modulation protein A;
DE Flags: Precursor;
GN Name=ampA; Synonyms=D11; ORFNames=DDB_G0275695;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=4033661; DOI=10.1128/mcb.5.6.1473-1479.1985;
RA Barklis E., Pontius B., Lodish H.F.;
RT "Structure of the Dictyostelium discoideum prestalk D11 gene and protein.";
RL Mol. Cell. Biol. 5:1473-1479(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- DEVELOPMENTAL STAGE: Present at low levels in the amoeboid and early
CC developing cells and reaches up to 20-fold higher levels during later
CC stages of development of the fruiting bodies.
CC {ECO:0000269|PubMed:4033661}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB03888.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M11012; AAB03888.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AAFI02000013; EAL69598.1; -; Genomic_DNA.
DR PIR; A23754; YPDOD1.
DR RefSeq; XP_643441.1; XM_638349.1.
DR AlphaFoldDB; P05817; -.
DR STRING; 44689.DDB0185088; -.
DR PaxDb; P05817; -.
DR EnsemblProtists; EAL69598; EAL69598; DDB_G0275695.
DR GeneID; 8620026; -.
DR KEGG; ddi:DDB_G0275695; -.
DR dictyBase; DDB_G0275695; ampA.
DR eggNOG; ENOG502RIDQ; Eukaryota.
DR HOGENOM; CLU_981513_0_0_1; -.
DR InParanoid; P05817; -.
DR PhylomeDB; P05817; -.
DR PRO; PR:P05817; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0071944; C:cell periphery; IDA:dictyBase.
DR GO; GO:0005576; C:extracellular region; IDA:dictyBase.
DR GO; GO:0031982; C:vesicle; IDA:dictyBase.
DR GO; GO:0030041; P:actin filament polymerization; IMP:dictyBase.
DR GO; GO:0007155; P:cell adhesion; IMP:dictyBase.
DR GO; GO:0016477; P:cell migration; IMP:dictyBase.
DR GO; GO:0098609; P:cell-cell adhesion; IMP:dictyBase.
DR GO; GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.
DR GO; GO:0043326; P:chemotaxis to folate; IMP:dictyBase.
DR GO; GO:0044351; P:macropinocytosis; IMP:dictyBase.
DR GO; GO:0007389; P:pattern specification process; IMP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome; Repeat; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..284
FT /note="Prestalk D11 protein"
FT /id="PRO_0000021058"
FT REPEAT 25..64
FT /note="A-1"
FT REPEAT 65..82
FT /note="B-1"
FT REPEAT 88..126
FT /note="A-2"
FT REPEAT 127..144
FT /note="B-2"
FT REPEAT 145..159
FT /note="C-1"
FT REPEAT 161..178
FT /note="B-3"
FT REPEAT 179..193
FT /note="C-2"
FT REPEAT 195..212
FT /note="B-4"
FT REPEAT 213..228
FT /note="C-3"
FT REPEAT 229..246
FT /note="B-5"
FT REPEAT 247..262
FT /note="C-4"
FT REPEAT 263..278
FT /note="B-6"
FT CONFLICT 7
FT /note="L -> R (in Ref. 1; AAB03888)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="R -> T (in Ref. 1; AAB03888)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="K -> Q (in Ref. 1; AAB03888)"
FT /evidence="ECO:0000305"
FT CONFLICT 252..254
FT /note="PDC -> RRW (in Ref. 1; AAB03888)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="D -> H (in Ref. 1; AAB03888)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 284 AA; 31009 MW; 6FCA2E493D4B514E CRC64;
MLNKLILLLI LSSCLVLSVK SEVNVDCSLV RCAQPICKPH YRLNMTDSCC GRCEPCTDVA
CTLQVKYCQD GEVPTGCCPC TLPPTKPDCS LVKCARPVCK PYYRLNMTDS CCGRCEPCTG
VACTLQIKYC KDGEVPTGCC PCTPQPTKKP DCSKVPCPKI LKYCQEGELP TGCCPCTPQP
TKKPDCSRVP CPKILKYCKE GELPTGCCPC TPQPTKKPDC SDVMCTMDIR YCKNGELPTG
CCPCTPQETK VPDCSKAMCT MDIKYCKPGE KPFGCCPCRE NLTQ
