ID   D130B_HUMAN             Reviewed;          79 AA.
AC   P0DP73; Q30KQ2;
DT   05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2017, sequence version 1.
DT   03-AUG-2022, entry version 21.
DE   RecName: Full=Beta-defensin 130B {ECO:0000305};
DE   Flags: Precursor;
GN   Name=DEFB130B {ECO:0000312|HGNC:HGNC:39814};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=28181499; DOI=10.1038/srep41772;
RA   Terkawi M.A., Takano R., Furukawa A., Murakoshi F., Kato K.;
RT   "Involvement of beta-defensin 130 (DEFB130) in the macrophage microbicidal
RT   mechanisms for killing Plasmodium falciparum.";
RL   Sci. Rep. 7:41772-41772(2017).
CC   -!- FUNCTION: Antimicrobial host-defense peptide. Has an antiplasmodial
CC       activity. {ECO:0000269|PubMed:28181499}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed on differentiated macrophage
CC       phagocytizing plasmodium falciparum-parasitized erythrocytes.
CC       {ECO:0000269|PubMed:28181499}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AC130366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS56524.1; -.
DR   RefSeq; NP_001032893.1; NM_001037804.1.
DR   RefSeq; NP_001182186.1; NM_001195257.1.
DR   AlphaFoldDB; P0DP73; -.
DR   SMR; P0DP73; -.
DR   BioMuta; DEFB130B; -.
DR   PeptideAtlas; P0DP73; -.
DR   PRIDE; P0DP73; -.
DR   DNASU; 245940; -.
DR   Ensembl; ENST00000437818.1; ENSP00000392568.1; ENSG00000233050.1.
DR   GeneID; 100133267; -.
DR   GeneID; 245940; -.
DR   KEGG; hsa:100133267; -.
DR   KEGG; hsa:245940; -.
DR   MANE-Select; ENST00000400079.1; ENSP00000382951.1; NM_001037804.1; NP_001032893.1.
DR   MANE-Select; ENST00000437818.1; ENSP00000392568.1; NM_001195257.1; NP_001182186.1.
DR   CTD; 100133267; -.
DR   CTD; 245940; -.
DR   GeneCards; DEFB130B; -.
DR   HGNC; HGNC:39814; DEFB130B.
DR   HPA; ENSG00000233050; Tissue enriched (epididymis).
DR   neXtProt; NX_P0DP73; -.
DR   VEuPathDB; HostDB:ENSG00000233050; -.
DR   OMA; DDTIGVC; -.
DR   OrthoDB; 1548768at2759; -.
DR   PathwayCommons; P0DP73; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   Pharos; P0DP73; Tdark.
DR   PRO; PR:P0DP73; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; P0DP73; protein.
DR   Bgee; ENSG00000233050; Expressed in urinary bladder and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..79
FT                   /note="Beta-defensin 130B"
FT                   /id="PRO_0000440984"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8736 MW;  65DF21FA1C40D507 CRC64;
     MKLHSLISVL LLFVTLIPKG KTGVIPGQKQ CIALKGVCRD KLCSTLDDTI GICNEGKKCC
     RRWWILEPYP TPVPKGKSP