D131A_HUMAN
ID D131A_HUMAN Reviewed; 70 AA.
AC P59861;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Beta-defensin 131A {ECO:0000305};
DE AltName: Full=Beta-defensin 31;
DE Short=DEFB-31;
DE AltName: Full=Defensin, beta 131 {ECO:0000312|HGNC:HGNC:18108};
DE Flags: Precursor;
GN Name=DEFB131A {ECO:0000312|HGNC:HGNC:18108};
GN Synonyms=DEFB131 {ECO:0000303|PubMed:12600824}, DEFB31;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12600824; DOI=10.1165/rcmb.2002-0205oc;
RA Kao C.Y., Chen Y., Zhao Y.H., Wu R.;
RT "ORFeome-based search of airway epithelial cell-specific novel human beta-
RT defensin genes.";
RL Am. J. Respir. Cell Mol. Biol. 29:71-80(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=26649771; DOI=10.1371/journal.pone.0144776;
RA Kim J.H., Kim K.H., Kim H.J., Lee J., Myung S.C.;
RT "Expression of Beta-Defensin 131 Promotes an Innate Immune Response in
RT Human Prostate Epithelial Cells.";
RL PLoS ONE 10:E0144776-E0144776(2015).
CC -!- FUNCTION: Has antibacterial activity (Probable). Upon stimulation with
CC lipoteichoic acid, promotes cytokines and chemokines production and
CC secretion (PubMed:26649771). {ECO:0000269|PubMed:26649771,
CC ECO:0000305}.
CC -!- INTERACTION:
CC P59861; O43765: SGTA; NbExp=5; IntAct=EBI-12304807, EBI-347996;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Is moderately expressed
CC in the prostate and small intestine. {ECO:0000269|PubMed:12600824}.
CC -!- INDUCTION: Up-regulated upon stimulation with lipoteichoic acid.
CC {ECO:0000269|PubMed:26649771}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AF529414; AAQ09523.1; -; mRNA.
DR EMBL; AC116655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC160155; AAI60155.1; -; mRNA.
DR CCDS; CCDS43213.1; -.
DR RefSeq; NP_001035538.2; NM_001040448.2.
DR AlphaFoldDB; P59861; -.
DR SMR; P59861; -.
DR BioGRID; 569591; 5.
DR IntAct; P59861; 1.
DR STRING; 9606.ENSP00000335538; -.
DR BioMuta; DEFB131A; -.
DR DMDM; 288558809; -.
DR PaxDb; P59861; -.
DR PeptideAtlas; P59861; -.
DR PRIDE; P59861; -.
DR ProteomicsDB; 57165; -.
DR Antibodypedia; 57939; 6 antibodies from 3 providers.
DR DNASU; 644414; -.
DR Ensembl; ENST00000334879.2; ENSP00000335538.1; ENSG00000186146.2.
DR GeneID; 644414; -.
DR KEGG; hsa:644414; -.
DR MANE-Select; ENST00000334879.2; ENSP00000335538.1; NM_001040448.3; NP_001035538.2.
DR UCSC; uc011bwt.2; human.
DR CTD; 644414; -.
DR GeneCards; DEFB131A; -.
DR HGNC; HGNC:18108; DEFB131A.
DR HPA; ENSG00000186146; Tissue enriched (epididymis).
DR neXtProt; NX_P59861; -.
DR OpenTargets; ENSG00000186146; -.
DR PharmGKB; PA38504; -.
DR VEuPathDB; HostDB:ENSG00000186146; -.
DR eggNOG; ENOG502TEDN; Eukaryota.
DR GeneTree; ENSGT00390000001538; -.
DR HOGENOM; CLU_203372_0_0_1; -.
DR InParanoid; P59861; -.
DR OMA; EYAVRYC; -.
DR OrthoDB; 1638187at2759; -.
DR PhylomeDB; P59861; -.
DR TreeFam; TF341399; -.
DR PathwayCommons; P59861; -.
DR Reactome; R-HSA-1461957; Beta defensins.
DR Reactome; R-HSA-1461973; Defensins.
DR SignaLink; P59861; -.
DR BioGRID-ORCS; 644414; 7 hits in 554 CRISPR screens.
DR ChiTaRS; DEFB131; human.
DR GenomeRNAi; 644414; -.
DR Pharos; P59861; Tbio.
DR PRO; PR:P59861; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; P59861; protein.
DR Bgee; ENSG00000186146; Expressed in duodenum and 66 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IMP:UniProtKB.
DR GO; GO:0071223; P:cellular response to lipoteichoic acid; IMP:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IMP:UniProtKB.
DR GO; GO:0032722; P:positive regulation of chemokine production; IMP:UniProtKB.
DR GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; IMP:UniProtKB.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IMP:UniProtKB.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PEPTIDE 23..70
FT /note="Beta-defensin 131A"
FT /id="PRO_0000007006"
FT DISULFID 29..56
FT /evidence="ECO:0000250"
FT DISULFID 36..50
FT /evidence="ECO:0000250"
FT DISULFID 40..57
FT /evidence="ECO:0000250"
FT CONFLICT 20
FT /note="A -> G (in Ref. 1; AAQ09523)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 70 AA; 8199 MW; 2A3DC536A4924F14 CRC64;
MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK
IIEIDGQKKW
