ID   D131A_PANTR             Reviewed;          71 AA.
AC   Q30KJ8;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Beta-defensin 131A {ECO:0000250|UniProtKB:P59861};
DE   AltName: Full=Defensin, beta 131 {ECO:0000250|UniProtKB:P59861};
DE   Flags: Precursor;
GN   Name=DEFB131A {ECO:0000250|UniProtKB:P59861};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity (Probable). Upon stimulation with
CC       lipoteichoic acid, promotes cytokines and chemokines production and
CC       secretion (By similarity). {ECO:0000250|UniProtKB:P59861, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012082; AAY59812.1; -; mRNA.
DR   RefSeq; NP_001123251.1; NM_001129779.1.
DR   AlphaFoldDB; Q30KJ8; -.
DR   STRING; 9598.ENSPTRP00000027407; -.
DR   PaxDb; Q30KJ8; -.
DR   Ensembl; ENSPTRT00000029705; ENSPTRP00000027407; ENSPTRG00000015911.
DR   GeneID; 743927; -.
DR   CTD; 644414; -.
DR   eggNOG; ENOG502TEDN; Eukaryota.
DR   GeneTree; ENSGT00390000001538; -.
DR   HOGENOM; CLU_203372_0_0_1; -.
DR   InParanoid; Q30KJ8; -.
DR   OMA; PSEYYYH; -.
DR   TreeFam; TF341399; -.
DR   Proteomes; UP000002277; Chromosome 4.
DR   Bgee; ENSPTRG00000015911; Expressed in fibroblast.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..71
FT                   /note="Beta-defensin 131A"
FT                   /id="PRO_0000045356"
FT   DISULFID        29..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..58
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8384 MW;  9B33C530A7D45FEC CRC64;
     MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYYHCRLK CNADEHAIRY CADFSICCKL
     KIIEIHGQKK W