ID   D131B_HUMAN             Reviewed;          70 AA.
AC   A0A096LNP1;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Beta-defensin 131B {ECO:0000305};
DE   AltName: Full=Defensin, beta 131 {ECO:0000312|HGNC:HGNC:38058};
DE   Flags: Precursor;
GN   Name=DEFB131B {ECO:0000312|HGNC:HGNC:38058};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AP002495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS76450.1; -.
DR   RefSeq; NP_001229782.1; NM_001242853.1.
DR   AlphaFoldDB; A0A096LNP1; -.
DR   SMR; A0A096LNP1; -.
DR   STRING; 9606.ENSP00000485141; -.
DR   BioMuta; DEFB131B; -.
DR   PeptideAtlas; A0A096LNP1; -.
DR   DNASU; 100129216; -.
DR   Ensembl; ENST00000530210.1; ENSP00000485141.1; ENSG00000225805.4.
DR   GeneID; 100129216; -.
DR   KEGG; hsa:100129216; -.
DR   MANE-Select; ENST00000530210.1; ENSP00000485141.1; NM_001242853.1; NP_001229782.1.
DR   UCSC; uc021qmu.1; human.
DR   CTD; 100129216; -.
DR   GeneCards; DEFB131B; -.
DR   HGNC; HGNC:38058; DEFB131B.
DR   HPA; ENSG00000225805; Tissue enriched (epididymis).
DR   neXtProt; NX_A0A096LNP1; -.
DR   VEuPathDB; HostDB:ENSG00000225805; -.
DR   eggNOG; ENOG502TEDN; Eukaryota.
DR   GeneTree; ENSGT00390000001538; -.
DR   HOGENOM; CLU_203372_0_0_1; -.
DR   OMA; PSEYYYH; -.
DR   OrthoDB; 1638187at2759; -.
DR   BioGRID-ORCS; 100129216; 7 hits in 141 CRISPR screens.
DR   GenomeRNAi; 100129216; -.
DR   Pharos; A0A096LNP1; Tdark.
DR   PRO; PR:A0A096LNP1; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; A0A096LNP1; protein.
DR   Bgee; ENSG00000225805; Expressed in corpus callosum and 87 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..70
FT                   /note="Beta-defensin 131B"
FT                   /id="PRO_0000441044"
FT   DISULFID        29..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..50
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..57
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   70 AA;  8156 MW;  5044FA93A488E499 CRC64;
     MRVLFFVFGV LSLMSTVPPT RSFTSNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK
     IIQIDGQKKW