D19L1_MOUSE
ID D19L1_MOUSE Reviewed; 746 AA.
AC A6X919; Q3UP31; Q8CD79;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Probable C-mannosyltransferase DPY19L1;
DE EC=2.4.1.-;
DE AltName: Full=Dpy-19-like protein 1;
DE AltName: Full=Protein dpy-19 homolog 1;
GN Name=Dpy19l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Spleen, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-220 (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-31, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation
CC of tryptophan residues on target proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A6X919-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6X919-2; Sequence=VSP_029630;
CC Name=3;
CC IsoId=A6X919-3; Sequence=VSP_029629, VSP_029631;
CC -!- SIMILARITY: Belongs to the dpy-19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CD352443; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK031291; BAC27335.1; -; mRNA.
DR EMBL; AK143845; BAE25566.1; -; mRNA.
DR EMBL; AC102554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT010514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116782; AAI16783.1; -; mRNA.
DR EMBL; BC116784; AAI16785.1; -; mRNA.
DR EMBL; CD352443; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS22931.2; -. [A6X919-1]
DR RefSeq; NP_766508.3; NM_172920.4. [A6X919-1]
DR RefSeq; XP_006510359.1; XM_006510296.3.
DR AlphaFoldDB; A6X919; -.
DR STRING; 10090.ENSMUSP00000129575; -.
DR iPTMnet; A6X919; -.
DR PhosphoSitePlus; A6X919; -.
DR EPD; A6X919; -.
DR jPOST; A6X919; -.
DR MaxQB; A6X919; -.
DR PaxDb; A6X919; -.
DR PeptideAtlas; A6X919; -.
DR PRIDE; A6X919; -.
DR ProteomicsDB; 279869; -. [A6X919-1]
DR ProteomicsDB; 279870; -. [A6X919-2]
DR ProteomicsDB; 279871; -. [A6X919-3]
DR Antibodypedia; 53188; 153 antibodies from 19 providers.
DR Ensembl; ENSMUST00000115277; ENSMUSP00000110932; ENSMUSG00000043067. [A6X919-2]
DR Ensembl; ENSMUST00000142064; ENSMUSP00000119986; ENSMUSG00000043067. [A6X919-1]
DR Ensembl; ENSMUST00000170356; ENSMUSP00000129575; ENSMUSG00000043067. [A6X919-1]
DR GeneID; 244745; -.
DR KEGG; mmu:244745; -.
DR UCSC; uc009ooz.3; mouse. [A6X919-3]
DR UCSC; uc009opa.3; mouse. [A6X919-1]
DR CTD; 23333; -.
DR MGI; MGI:1915685; Dpy19l1.
DR VEuPathDB; HostDB:ENSMUSG00000043067; -.
DR eggNOG; KOG4587; Eukaryota.
DR GeneTree; ENSGT00530000063023; -.
DR HOGENOM; CLU_014404_0_1_1; -.
DR InParanoid; A6X919; -.
DR OMA; HDPLQGD; -.
DR OrthoDB; 1115173at2759; -.
DR PhylomeDB; A6X919; -.
DR TreeFam; TF313376; -.
DR BRENDA; 2.4.1.B72; 3474.
DR BioGRID-ORCS; 244745; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Dpy19l1; mouse.
DR PRO; PR:A6X919; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; A6X919; protein.
DR Bgee; ENSMUSG00000043067; Expressed in cortical plate and 236 other tissues.
DR Genevisible; A6X919; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005637; C:nuclear inner membrane; IBA:GO_Central.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0018406; P:protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan; IBA:GO_Central.
DR InterPro; IPR018732; Dpy-19/Dpy-19-like.
DR InterPro; IPR030041; DPY19L1.
DR PANTHER; PTHR31488; PTHR31488; 1.
DR PANTHER; PTHR31488:SF5; PTHR31488:SF5; 1.
DR Pfam; PF10034; Dpy19; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycosyltransferase; Membrane; Phosphoprotein;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..746
FT /note="Probable C-mannosyltransferase DPY19L1"
FT /id="PRO_0000311878"
FT TRANSMEM 137..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 28
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..551
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029629"
FT VAR_SEQ 1..194
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029630"
FT VAR_SEQ 552..560
FT /note="VMASLICSR -> MVTRGFLEF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029631"
FT CONFLICT 208
FT /note="V -> A (in Ref. 3; CD352443)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 746 AA; 84187 MW; C2C6007141CAE426 CRC64;
MVLQARSKHR DAAPRPPRSA RSSPPPLSGA SEVDAGELGS ERTPPSPGRR GAAGRKGPRA
GTAAPAPDGL AGRLAAGLHW ALGLRRGRGR TWSTLLLASF AALLHWSHIT HLFENDRHFS
HLSTLEREMA FRTEMGLYYS YFKTIVEAPS FLNGVWMIMN DKLTEYPLVI NTLKRFNLYP
EVILASWYRI YTKIMDLIGI QTKICWTVTR GEGLSPIESC EGLGDPACFY VAVIFMLNGL
MMALFFIYGT YLSGSRLGGV VTVLCFFFNH GECTRVMWTP PLRESFSYPF LVLQMLLVTH
ILRAPELCRG SLIALCISNV LFMLPWQFAQ FVLLTQIASL FAVYVVGYID THKLQKIIYM
HMISLVLCFV LMFGNSMLLT SYYASSLVII WGMLAMKPQF LRMNVSELSL WVIQGCGWLF
GTVILKSVTS RIFGIADDAH IGNLLTSKFF SYKDFDTLLY TCAAEFDFME KETPLRYTKT
LLLPVVLVTV AAIVRKIFND MRGVVAKQRT HTRKQQFEHG ELVYHALQLL AYTALGVLIM
RLKLFLTPHM CVMASLICSR QLFGWLFGKV HPGAVVFAIL AAMSIQGSAN LQTQWNIVGE
FSNLPQEELI EWIRYSTKPD AVFAGAMPTM ASVKLSALRP VVNHPHYEDA GLRARTKIVY
SMYSRKAPED VKKELMKLKV NYYILEESWC IRRSKPGCSM PEIWDVEDPD NAGKTPLCNI
LVKDSKPHFT TVFQNSVYKV LEVLRQ
