D19L3_MOUSE
ID D19L3_MOUSE Reviewed; 716 AA.
AC Q71B07; Q6PB46; Q80W29; Q8BLA9; Q8BZL3; Q8BZW5;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Probable C-mannosyltransferase DPY19L3;
DE EC=2.4.1.-;
DE AltName: Full=Dpy-19-like protein 3;
DE AltName: Full=Protein dpy-19 homolog 3;
GN Name=Dpy19l3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RA Ding P., Han W., Rui M., Wang Y., Song Q., Zhang Y., Ma D.;
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Diencephalon, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation
CC of tryptophan residues on target proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the dpy-19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH59897.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF538322; AAQ10888.1; -; mRNA.
DR EMBL; AK033395; BAC28266.1; -; mRNA.
DR EMBL; AK034217; BAC28636.1; -; mRNA.
DR EMBL; AK045758; BAC32483.1; -; mRNA.
DR EMBL; BC050065; AAH50065.1; -; mRNA.
DR EMBL; BC059897; AAH59897.1; ALT_FRAME; mRNA.
DR CCDS; CCDS21155.1; -.
DR RefSeq; NP_848819.2; NM_178704.3.
DR AlphaFoldDB; Q71B07; -.
DR BioGRID; 231376; 1.
DR STRING; 10090.ENSMUSP00000054747; -.
DR iPTMnet; Q71B07; -.
DR PhosphoSitePlus; Q71B07; -.
DR EPD; Q71B07; -.
DR MaxQB; Q71B07; -.
DR PaxDb; Q71B07; -.
DR PeptideAtlas; Q71B07; -.
DR PRIDE; Q71B07; -.
DR ProteomicsDB; 279357; -.
DR Antibodypedia; 2035; 101 antibodies from 15 providers.
DR DNASU; 233115; -.
DR Ensembl; ENSMUST00000051377; ENSMUSP00000054747; ENSMUSG00000043671.
DR GeneID; 233115; -.
DR KEGG; mmu:233115; -.
DR UCSC; uc009gkg.2; mouse.
DR CTD; 147991; -.
DR MGI; MGI:2443952; Dpy19l3.
DR VEuPathDB; HostDB:ENSMUSG00000043671; -.
DR eggNOG; KOG4587; Eukaryota.
DR GeneTree; ENSGT00530000063023; -.
DR HOGENOM; CLU_014404_1_0_1; -.
DR InParanoid; Q71B07; -.
DR OMA; FSLAWQF; -.
DR OrthoDB; 1115173at2759; -.
DR PhylomeDB; Q71B07; -.
DR TreeFam; TF313376; -.
DR BRENDA; 2.4.1.B72; 3474.
DR BioGRID-ORCS; 233115; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Dpy19l3; mouse.
DR PRO; PR:Q71B07; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q71B07; protein.
DR Bgee; ENSMUSG00000043671; Expressed in embryonic post-anal tail and 208 other tissues.
DR ExpressionAtlas; Q71B07; baseline and differential.
DR Genevisible; Q71B07; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005637; C:nuclear inner membrane; IBA:GO_Central.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0018406; P:protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan; IBA:GO_Central.
DR InterPro; IPR018732; Dpy-19/Dpy-19-like.
DR InterPro; IPR030039; DPY19L3.
DR PANTHER; PTHR31488; PTHR31488; 1.
DR PANTHER; PTHR31488:SF4; PTHR31488:SF4; 1.
DR Pfam; PF10034; Dpy19; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase; Membrane; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..716
FT /note="Probable C-mannosyltransferase DPY19L3"
FT /id="PRO_0000311902"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..509
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 208
FT /note="T -> A (in Ref. 3; AAH50065)"
FT /evidence="ECO:0000305"
FT CONFLICT 210
FT /note="P -> T (in Ref. 2; BAC28266)"
FT /evidence="ECO:0000305"
FT CONFLICT 382..383
FT /note="FG -> LV (in Ref. 1; AAQ10888)"
FT /evidence="ECO:0000305"
FT CONFLICT 539
FT /note="S -> P (in Ref. 2; BAC28636)"
FT /evidence="ECO:0000305"
FT CONFLICT 590
FT /note="G -> R (in Ref. 3; AAH50065)"
FT /evidence="ECO:0000305"
FT CONFLICT 650
FT /note="G -> S (in Ref. 3; AAH50065)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 716 AA; 82990 MW; E801A69F9E8F9E93 CRC64;
MMYIRQRKET KPIEVSEDFP SPKEDVKLEK KLPSGCASGR FWKILSSAVG GTVALCIGLL
TSVYLATLHE NDLWFSNIKE VEREISFRTE CGLYYSYYKQ MLQAPTLLQG FHGLIYDNKT
ESMRTINLLQ RMNIYQEVFL SVLYRVLPIQ KYLEPVYFYI YTLFGLQAVY VTALYITSWL
LSGTWLSGLL AALWYVTNRI DTTRVEFTIP LRENWALPFF AIQIAAITYF LRPNLQPLSE
RLTLLAIFVS TFLFSLTWQF NQFMMLLQAL VLFILDSLDM LPAMKATWLY GIQISCLLLV
CTLQFFNSMI LGSLLISFNL SVLIVRKLQK NLKTGSFLTR IWKLLLHLLL VFCLTLFLNN
IIKKVLNLKS DEHIFKFLKA KFGFGATRDF DANLYLCEEA FGLLPLNTFQ RLSETLLFYA
YMFVLVVTVV TASVVAFHNL SDSTSLKSMD QTRKRAVDLK PEAAYNLIHT ILFGVLALST
MRMKYLWTSH MCVFASFGLC SSEVWELLLR LVHLCNPKRI WVLRYLVPVL TLLYLCYKSW
PGVMDELSEL KEFYDPDTVE LMTWINSNTP RKAVFAGSMQ LLAGVKLCTG RTLTNHPHYE
DKSLRERTQA VYQIYAKRSP EEVHALLRSF GTDFVILEDS ICYERRHHRG CRLRDLLDVA
NGHEMDGPGE SDPDLRPADH PRFCEEIKRN LPSYAAHFTR VFQNKTFHVY KLSRNK
