ID   D19L3_PONAB             Reviewed;         690 AA.
AC   Q5RCJ4;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Probable C-mannosyltransferase DPY19L3;
DE            EC=2.4.1.-;
DE   AltName: Full=Dpy-19-like protein 3;
DE   AltName: Full=Protein dpy-19 homolog 3;
GN   Name=DPY19L3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation
CC       of tryptophan residues on target proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the dpy-19 family. {ECO:0000305}.
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DR   EMBL; CR858276; CAH90513.1; -; mRNA.
DR   RefSeq; NP_001125270.1; NM_001131798.1.
DR   AlphaFoldDB; Q5RCJ4; -.
DR   STRING; 9601.ENSPPYP00000010991; -.
DR   GeneID; 100172167; -.
DR   KEGG; pon:100172167; -.
DR   CTD; 147991; -.
DR   eggNOG; KOG4587; Eukaryota.
DR   InParanoid; Q5RCJ4; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018732; Dpy-19/Dpy-19-like.
DR   InterPro; IPR030039; DPY19L3.
DR   PANTHER; PTHR31488; PTHR31488; 1.
DR   PANTHER; PTHR31488:SF4; PTHR31488:SF4; 1.
DR   Pfam; PF10034; Dpy19; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Membrane; Reference proteome; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..690
FT                   /note="Probable C-mannosyltransferase DPY19L3"
FT                   /id="PRO_0000311903"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        527..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          668..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   690 AA;  79789 MW;  04994A315DDADB2E CRC64;
     MMSIRQRREI RATEVSEDFP AQEENVKLEN KLPSGCTSRR LWKILSLTIG GTIALCIGLL
     TSVYPATLHE NDLWFSNIKE VEREISFRTE CGLYYSYYKQ MLQAPTLVQG FYGLIYDNKT
     ESMKTINLLQ RMNIYQEVFL SILYRVLPVQ KYLEPVYFYI YTLFGLQAIY VTALYITSWL
     LSGTWLSGLL AAFWYVTNRI DTTRVEFTIP LRENWALPFF AIQIAAITYF LRPNLQPLSE
     RLTLLAIFIS TFLFSLTWQF NQFMMLMQAL VLFTLDSLDM LPAVKATWLY GIQITSLLLV
     CILQFFNSMI LGSLLISFNL SVFIARKLQK NLKTGSFLNR LGKLLLHLFM VLCLTLFLNN
     IIKKILNLKS DEHIFKFLKA KFGLGATRDF DANLYLREEA FGLLPFNTFG RLSDTLLFYA
     YIFVLSITVI VAFVVAFHNL SDSTNQQSVG KMEKGTVDLK PETAYNLIHT ILFGFLALST
     MRMKYLWTSH MCVFASFGLC SPEIWELLLK SVHLYNPKRI CIMRYSVPIL ILLYLCYKFW
     PGMMDELSEL REFYDPDTVE LMNWINSNTP RKAVFAGSMQ LLAGVKLCTG RTLTNHPHYE
     DSSLRERTRA VYQIYAKRAP EEVHALLRSF GTDYVILEDS ICYERRHRRG CRLRDLLDIA
     NGHNPSLGTL VTATGAGQGR DDGWPRRERS