ID   D19L4_PONAB             Reviewed;         686 AA.
AC   Q5R8N9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Probable C-mannosyltransferase DPY19L4;
DE            EC=2.4.1.-;
DE   AltName: Full=Dpy-19-like protein 4;
DE   AltName: Full=Protein dpy-19 homolog 4;
GN   Name=DPY19L4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation
CC       of tryptophan residues on target proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the dpy-19 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH91871.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR859712; CAH91871.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001126084.1; NM_001132612.1.
DR   AlphaFoldDB; Q5R8N9; -.
DR   GeneID; 100173037; -.
DR   KEGG; pon:100173037; -.
DR   CTD; 286148; -.
DR   eggNOG; KOG4587; Eukaryota.
DR   InParanoid; Q5R8N9; -.
DR   OrthoDB; 1115173at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018732; Dpy-19/Dpy-19-like.
DR   InterPro; IPR030040; DPY19L4.
DR   PANTHER; PTHR31488; PTHR31488; 1.
DR   PANTHER; PTHR31488:SF2; PTHR31488:SF2; 1.
DR   Pfam; PF10034; Dpy19; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Glycosyltransferase; Membrane; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z388"
FT   CHAIN           2..686
FT                   /note="Probable C-mannosyltransferase DPY19L4"
FT                   /id="PRO_0000311883"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        452..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        485..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z388"
SQ   SEQUENCE   686 AA;  79604 MW;  F6D52DCE05E77CEA CRC64;
     MAEEEDVLFQ RFAKIFIGCL AAVTSGMMYA LYLSAYHERK FWFSNRQELE REITFQGDSA
     IYYSYYKDML KAPSFERGVY ELTHNNKTVS LKTINAVQQM SLYPELIASV LYQATGSKEI
     IEPVYFYIGI VFGLQGIYVT ALFVTSWLMS GTWLAGMLTV AWFIINRVDT TRIEYSIPLR
     ENWALPYFAC QIAALTGYLK SNLNTYGERF CYLLMSASTY TFMMMWEYSH YLLFLQVISL
     FLLDIFSVEQ SDKVYEVYKI YIFSLFLGYL LQFENPALLV SPLLSLVAAL MLAKCLQLNV
     KKGSFVAKII KVINFYLVCT LTITLNIIMK MFVPHKENGH MLKFLEVKFG LNMTKNFTMN
     WLLCQESLQA PSQDFFLRLT QSSLLPFYIL VLIICFLSML QVIFRRINGK SLKETITLED
     GRIGERPEII YHVIHTILLG SLAMVIEGLK YIWIPYVCML AAFGVCSPEL WMTLFKWLRL
     RTVHPILLAL ILSMAVPTII GLSLWKEFFP RLMTELMELQ EFYDPDTVEL MTWIKRQAPV
     AAVFAGSPQL MGAIKLCTGW MVTSLPLYND DDLLKRNENI YQIYSKRSAE DIYKILTSYK
     ANYLIVEDAI CNEVGPIRGC RVKDLLDIAN GHMVCEEGDK LTYSKYGRFC HEVKINYSPY
     VNYFTRVYWN RSYFVYKINT VISFQS