D19P1_HUMAN
ID D19P1_HUMAN Reviewed; 242 AA.
AC Q6NXN4; B4E2E3;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Putative C-mannosyltransferase DPY19L2P1;
DE EC=2.4.1.-;
DE AltName: Full=Dpy-19-like protein 2 pseudogene 1;
DE AltName: Full=Protein dpy-19 homolog 2-like 1;
GN Name=DPY19L2P1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP GENE DUPLICATION, AND TISSUE SPECIFICITY.
RX PubMed=16526957; DOI=10.1186/1471-2164-7-45;
RA Carson A.R., Cheung J., Scherer S.W.;
RT "Duplication and relocation of the functional DPY19L2 gene within low copy
RT repeats.";
RL BMC Genomics 7:45-45(2006).
CC -!- FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation
CC of tryptophan residues on target proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Brain, heart, placenta and testis.
CC {ECO:0000269|PubMed:16526957}.
CC -!- MISCELLANEOUS: It has been suggested that DPY19L2P1 is an inactive
CC pseudogene from which DPY19L2 has evolved by duplication. However,
CC expressed transcript sequences derived from the DPY19L2P1 locus are
CC known to exist.
CC -!- SIMILARITY: Belongs to the dpy-19 family. {ECO:0000305}.
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DR EMBL; AK304236; BAG65105.1; -; mRNA.
DR AlphaFoldDB; Q6NXN4; -.
DR iPTMnet; Q6NXN4; -.
DR PhosphoSitePlus; Q6NXN4; -.
DR BioMuta; HGNC:22305; -.
DR MassIVE; Q6NXN4; -.
DR PeptideAtlas; Q6NXN4; -.
DR PRIDE; Q6NXN4; -.
DR ProteomicsDB; 66757; -.
DR GeneCards; DPY19L2P1; -.
DR HGNC; HGNC:22305; DPY19L2P1.
DR neXtProt; NX_Q6NXN4; -.
DR InParanoid; Q6NXN4; -.
DR PhylomeDB; Q6NXN4; -.
DR PathwayCommons; Q6NXN4; -.
DR Pharos; Q6NXN4; Tdark.
DR PRO; PR:Q6NXN4; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6NXN4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0007286; P:spermatid development; IEA:InterPro.
DR InterPro; IPR018732; Dpy-19/Dpy-19-like.
DR InterPro; IPR030042; DPY19L2.
DR PANTHER; PTHR31488; PTHR31488; 1.
DR PANTHER; PTHR31488:SF6; PTHR31488:SF6; 1.
DR Pfam; PF10034; Dpy19; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase; Membrane; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..242
FT /note="Putative C-mannosyltransferase DPY19L2P1"
FT /id="PRO_0000311880"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 242 AA; 28036 MW; 6AEC9F72F4DBE234 CRC64;
MKKQGVNPKP LQSSRPSPSK RPYGASPARE LEVEKSALGG GKLPGGARRS SPGRIPNLKK
RKGLELKVVA KTLLDPFQFV RNSLAQLREE VHELQARWFP SRTTLSIAIF VAILHWLHLV
TLFENDRHFS HLSSLEWEMT FRTKMGLYYS YFKTIIEAPS FLEGLWMIMN DRLTEYPLVI
NTVKRFHLYP EVIIAAWYRT FIGIMNLFGL ETKTCWNVTR IEPLNEFKAV KDWEILLAFM
LV
