ID   D1B_HADVE               Reviewed;          42 AA.
AC   P81885;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Delta-hexatoxin-Hv1b {ECO:0000305};
DE            Short=Delta-HXTX-Hv1b {ECO:0000305};
DE   AltName: Full=Delta-atracotoxin-Hv1b {ECO:0000303|PubMed:10745084};
DE            Short=Delta-ACTX-Hv1b {ECO:0000303|PubMed:10745084};
OS   Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Hexathelidae; Hadronyche.
OX   NCBI_TaxID=6904;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=10745084; DOI=10.1016/s0014-5793(00)01339-9;
RA   Szeto T.H., Birinyi-Strachan L.C., Smith R., Connor M., Christie M.J.,
RA   King G.F., Nicholson G.M.;
RT   "Isolation and pharmacological characterisation of delta-atracotoxin-Hv1b,
RT   a vertebrate-selective sodium channel toxin.";
RL   FEBS Lett. 470:293-299(2000).
CC   -!- FUNCTION: Lethal neurotoxin. Slows the inactivation of tetrodotoxin-
CC       sensitive voltage-gated sodium channels (Nav) by binding to site 3 of
CC       the channel, resulting in repetitive firing in autonomic and motor
CC       nerve fibers. {ECO:0000269|PubMed:10745084}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10745084}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:10745084}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:P13494}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 06 (delta-actx) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P81885; -.
DR   SMR; P81885; -.
DR   ArachnoServer; AS000170; delta-hexatoxin-Hv1b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008017; Atracotoxin_delta.
DR   Pfam; PF05353; Atracotoxin; 1.
DR   PROSITE; PS60018; DELTA_ACTX; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..42
FT                   /note="Delta-hexatoxin-Hv1b"
FT                   /evidence="ECO:0000269|PubMed:10745084"
FT                   /id="PRO_0000087655"
FT   DISULFID        1..15
FT                   /evidence="ECO:0000250|UniProtKB:P13494"
FT   DISULFID        8..20
FT                   /evidence="ECO:0000250|UniProtKB:P13494"
FT   DISULFID        14..31
FT                   /evidence="ECO:0000250|UniProtKB:P13494"
FT   DISULFID        16..42
FT                   /evidence="ECO:0000250|UniProtKB:P13494"
SQ   SEQUENCE   42 AA;  4779 MW;  3FA811B82AF12D17 CRC64;
     CSRSDGWCGK TEDCCCPMKC IKAWYKQNGN CQNTISAIWK NC