ID   D2_VACCW                Reviewed;         146 AA.
AC   P04300; Q76ZS5;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   23-FEB-2022, entry version 58.
DE   RecName: Full=Core protein D2;
GN   OrderedLocusNames=VACWR107; ORFNames=D2L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3739227; DOI=10.1016/0042-6822(86)90011-5;
RA   Niles E.G., Condit R.C., Caro P., Davidson K., Matusick L., Seto J.;
RT   "Nucleotide sequence and genetic map of the 16-kb vaccinia virus HindIII D
RT   fragment.";
RL   Virology 153:96-112(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   INDUCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=2024484; DOI=10.1016/0042-6822(91)90586-z;
RA   Dyster L.M., Niles E.G.;
RT   "Genetic and biochemical characterization of vaccinia virus genes D2L and
RT   D3R which encode virion structural proteins.";
RL   Virology 182:455-467(1991).
RN   [4]
RP   IDENTIFICATION IN COMPLEX WITH A30; F10; A15; G7; D3 AND J1.
RX   PubMed=15567438; DOI=10.1016/j.virol.2004.10.008;
RA   Szajner P., Jaffe H., Weisberg A.S., Moss B.;
RT   "A complex of seven vaccinia virus proteins conserved in all
RT   chordopoxviruses is required for the association of membranes and viroplasm
RT   to form immature virions.";
RL   Virology 330:447-459(2004).
CC   -!- FUNCTION: Late protein which is part of a large complex required for
CC       early virion morphogenesis. This complex participates in the formation
CC       of virosomes and the incorporation of virosomal contents into nascent
CC       immature virions.
CC   -!- SUBUNIT: Part of a complex composed of A30, G7, F10 kinase, A15, D2,
CC       D3, and J1. {ECO:0000269|PubMed:15567438}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:2024484}.
CC       Note=Localizes to the virion core.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:2024484}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae D2 family. {ECO:0000305}.
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DR   EMBL; M15058; AAA48255.1; -; Genomic_DNA.
DR   EMBL; AY243312; AAO89386.1; -; Genomic_DNA.
DR   PIR; A03874; QQVZ3.
DR   RefSeq; YP_232989.1; NC_006998.1.
DR   DNASU; 3707563; -.
DR   GeneID; 3707563; -.
DR   KEGG; vg:3707563; -.
DR   Proteomes; UP000000344; Genome.
DR   InterPro; IPR006791; Pox_D2.
DR   Pfam; PF04701; Pox_D2; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Reference proteome; Virion.
FT   CHAIN           1..146
FT                   /note="Core protein D2"
FT                   /id="PRO_0000099424"
SQ   SEQUENCE   146 AA;  16946 MW;  32EBD9339987832A CRC64;
     MSINIDIKKI TDLLNSSILF PDDVQELLRE KYIVLERKSN GTPTVAHIYK TMARFDNKSI
     YRIAKFLFMN RPDVIKLLFL KDVEPLLPDK SINISINNTE YPQLEGPIGT KIALLELFNA
     FRTGRSEPIP YYYLPLRKDI NNIVTK