ID   D2_VAR67                Reviewed;         146 AA.
AC   P0DOS2; P33060;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 7.
DE   RecName: Full=Core protein D2;
GN   ORFNames=D2L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383392; DOI=10.1016/0168-1702(93)90110-9;
RA   Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S.,
RA   Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V.,
RA   Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G.,
RA   Sandakhchiev L.S.;
RT   "Nucleotide sequence analysis of variola virus HindIII M, L, I genome
RT   fragments.";
RL   Virus Res. 27:25-35(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Late protein which is part of a large complex required for
CC       early virion morphogenesis. This complex participates in the formation
CC       of virosomes and the incorporation of virosomal contents into nascent
CC       immature virions (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex composed of A30, G7, F10 kinase, A15, D2,
CC       D3, and J1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes to the
CC       virion core. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae D2 family. {ECO:0000305}.
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DR   EMBL; X67119; CAA47591.1; -; Genomic_DNA.
DR   EMBL; X69198; CAA49034.1; -; Genomic_DNA.
DR   PIR; S33106; S33106.
DR   RefSeq; NP_042136.1; NC_001611.1.
DR   GeneID; 1486418; -.
DR   KEGG; vg:1486418; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR006791; Pox_D2.
DR   Pfam; PF04701; Pox_D2; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Reference proteome; Virion.
FT   CHAIN           1..146
FT                   /note="Core protein D2"
FT                   /id="PRO_0000099425"
SQ   SEQUENCE   146 AA;  16876 MW;  2A72781391BEA23A CRC64;
     MSINIDIKKI TDLLNSSILF PDDVQELLRE KYIVLERKSN GTPTVAHIYK TMARFDNKSI
     YRIAKFLFMN RPDVIKLLFL EDVEPLLPDK SINISINNTE YPQLEGPIGT KIALLELFNA
     FKTGISEPIP YYYLPLRKDI NNIVTK