D39U1_MOUSE
ID D39U1_MOUSE Reviewed; 293 AA.
AC Q5M8N4; Q3V467; Q8BWX0;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-FEB-2019, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Epimerase family protein SDR39U1;
DE EC=1.1.1.-;
DE AltName: Full=Short-chain dehydrogenase/reductase family 39U member 1 {ECO:0000250|UniProtKB:Q9NRG7};
GN Name=Sdr39u1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal cord, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Putative NADP-dependent oxidoreductase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. SDR39U1 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH87941.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK009339; BAE43214.1; -; mRNA.
DR EMBL; AK049709; BAC33886.1; -; mRNA.
DR EMBL; BC087941; AAH87941.1; ALT_TERM; mRNA.
DR CCDS; CCDS36935.1; -.
DR RefSeq; NP_001076444.1; NM_001082975.1.
DR AlphaFoldDB; Q5M8N4; -.
DR SMR; Q5M8N4; -.
DR STRING; 10090.ENSMUSP00000106957; -.
DR iPTMnet; Q5M8N4; -.
DR PhosphoSitePlus; Q5M8N4; -.
DR EPD; Q5M8N4; -.
DR jPOST; Q5M8N4; -.
DR MaxQB; Q5M8N4; -.
DR PaxDb; Q5M8N4; -.
DR PeptideAtlas; Q5M8N4; -.
DR PRIDE; Q5M8N4; -.
DR ProteomicsDB; 279259; -.
DR Antibodypedia; 22920; 92 antibodies from 19 providers.
DR Ensembl; ENSMUST00000111325; ENSMUSP00000106957; ENSMUSG00000022223.
DR GeneID; 654795; -.
DR KEGG; mmu:654795; -.
DR UCSC; uc007ubc.1; mouse.
DR CTD; 56948; -.
DR MGI; MGI:1916876; Sdr39u1.
DR VEuPathDB; HostDB:ENSMUSG00000022223; -.
DR eggNOG; KOG3019; Eukaryota.
DR GeneTree; ENSGT00390000000337; -.
DR HOGENOM; CLU_047373_0_1_1; -.
DR InParanoid; Q5M8N4; -.
DR OMA; YMPWIHI; -.
DR OrthoDB; 1498565at2759; -.
DR PhylomeDB; Q5M8N4; -.
DR TreeFam; TF324783; -.
DR BioGRID-ORCS; 654795; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Sdr39u1; mouse.
DR PRO; PR:Q5M8N4; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q5M8N4; protein.
DR Bgee; ENSMUSG00000022223; Expressed in embryonic brain and 183 other tissues.
DR ExpressionAtlas; Q5M8N4; baseline and differential.
DR Genevisible; Q5M8N4; MM.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR013549; DUF1731.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR010099; SDR39U1.
DR Pfam; PF08338; DUF1731; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR01777; yfcH; 1.
PE 1: Evidence at protein level;
KW NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..293
FT /note="Epimerase family protein SDR39U1"
FT /id="PRO_0000279749"
FT BINDING 31..32
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:Q9NRG7"
FT BINDING 58..59
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:Q9NRG7"
FT BINDING 77
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:Q9NRG7"
FT BINDING 82
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:Q9NRG7"
FT BINDING 160
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:Q9NRG7"
FT CONFLICT 132
FT /note="F -> S (in Ref. 1; BAE43214)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 293 AA; 31458 MW; C9A50AF7FE0B05A9 CRC64;
MRVLVGGGTG FIGTAVTQLL RGRGHEVKLV SRQPGPGRIT WSELSESGLP LCDVVINLAG
ENILNPLRRW NETFQKEVLT SRLDTTHLLA KAITETAHPP QAWILVTGVA YYQPSLTKEY
DEDSPGGNFD FFSNLVTKWE AAARLPGEST RQVVVRSGVV LGRGGGAISH MLLPFRLGLG
GPIGSGRQFF PWIHIGDLAG ILNYALEANH VQGVLNGVAP ASTTTNAEFA QALGAALGRP
AFIPVPSTVV RAVFGERAIM LLEGQKVVPR RTLATGYQYS FPELRAALKD VVA
