ID   D3_VAR67                Reviewed;         237 AA.
AC   P0DSQ9; P33068; Q76Q04;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 6.
DE   RecName: Full=Core protein D3;
DE   AltName: Full=27 kDa virion core protein;
GN   ORFNames=D3R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383392; DOI=10.1016/0168-1702(93)90110-9;
RA   Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S.,
RA   Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V.,
RA   Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G.,
RA   Sandakhchiev L.S.;
RT   "Nucleotide sequence analysis of variola virus HindIII M, L, I genome
RT   fragments.";
RL   Virus Res. 27:25-35(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Late protein which is part of a large complex required for
CC       early virion morphogenesis. This complex participates in the formation
CC       of virosomes and the incorporation of virosomal contents into nascent
CC       immature virions (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex composed of A30, G7, F10 kinase, A15, D2,
CC       D3, and J1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes to the
CC       virion core. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae D3 family. {ECO:0000305}.
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DR   EMBL; X67119; CAA47592.1; -; Genomic_DNA.
DR   EMBL; X69198; CAA49033.1; -; Genomic_DNA.
DR   PIR; S33107; S33107.
DR   RefSeq; NP_042137.1; NC_001611.1.
DR   GeneID; 1486419; -.
DR   KEGG; vg:1486419; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR007660; Pox_D3.
DR   Pfam; PF04580; Pox_D3; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Reference proteome; Virion.
FT   CHAIN           1..237
FT                   /note="Core protein D3"
FT                   /id="PRO_0000099431"
SQ   SEQUENCE   237 AA;  27996 MW;  3A65D7C240C76596 CRC64;
     MDIFIVKDNK YPKVDNDDNE VFILLGNHND FIRSKLTKLK EHVFFSKYIV TPDTYGSLCV
     ELNGSSFQHG GRYIEVEEFI DDGRQVRWCS TSNHISEDIP EDIHTNKFII YDIYTFDSFK
     NKRLVFVQVP TSLGDDSYLT NPLLSPYYCN SVARQMVNDM IFNQDSFLKY LLEHLIRSHY
     RVSKHITIVR YKDTEELNLT RICYNRDKFK AFAFAWFNGV LENEKVLDTY KKVSDLI