ID   D42E1_MACFA             Reviewed;         393 AA.
AC   Q4R7R1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Short-chain dehydrogenase/reductase family 42E member 1 {ECO:0000250|UniProtKB:Q8WUS8};
DE            EC=1.1.1.-;
GN   Name=SDR42E1; ORFNames=QtsA-14586;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family. {ECO:0000305}.
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DR   EMBL; AB168754; BAE00861.1; -; mRNA.
DR   RefSeq; NP_001270911.1; NM_001283982.1.
DR   RefSeq; XP_005592697.1; XM_005592640.2.
DR   RefSeq; XP_005592698.1; XM_005592641.2.
DR   RefSeq; XP_005592699.1; XM_005592642.2.
DR   RefSeq; XP_005592700.1; XM_005592643.2.
DR   AlphaFoldDB; Q4R7R1; -.
DR   SMR; Q4R7R1; -.
DR   STRING; 9541.XP_005592696.1; -.
DR   Ensembl; ENSMFAT00000016984; ENSMFAP00000042700; ENSMFAG00000040108.
DR   GeneID; 101925751; -.
DR   KEGG; mcf:101925751; -.
DR   CTD; 93517; -.
DR   VEuPathDB; HostDB:ENSMFAG00000040108; -.
DR   eggNOG; KOG1430; Eukaryota.
DR   GeneTree; ENSGT00940000158070; -.
DR   OMA; GAYKRSK; -.
DR   OrthoDB; 992332at2759; -.
DR   Proteomes; UP000233100; Chromosome 20.
DR   Bgee; ENSMFAG00000040108; Expressed in liver and 9 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Membrane; NAD; Oxidoreductase; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..393
FT                   /note="Short-chain dehydrogenase/reductase family 42E
FT                   member 1"
FT                   /id="PRO_0000331755"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        152
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         156
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   393 AA;  44128 MW;  94B66203D3A5D0F8 CRC64;
     MDPKRSQKET VLITGGGGYF GFRLGCALNQ KGVHVILFDI SSPAETIPEG IKFIQGDICH
     LSDIEKAFQD ADITCVFHIA SYGMSGREQL NRNLIEEVNI GGTDNILQAC QRRRVPRLVY
     TSTFNVIFGG QVIRNGDESL PYLPLHLHPD HYSRTKSIAE KKVLEANGTP LDRGDGVLRT
     CALRPAGIYG PGEQRHLPRI VSYIEKGLFK FVYGDPRSLV EFVHVDNLVQ AHILASEALR
     ADKGHIASGQ PYFISDGRPV NNFEFFRPLV EGLGYTFPST RLPLTLVYCF AFLTEMVHFI
     LGRLYNFQPF LTRTEVYKTG VTHYFSLEKA KKELGYKAQP FDLQEAVEWF KAHGHGRSSG
     SRDSECFIWD GLLVFLLIIA VLIWLPSSVI LSL