ID   D42E1_XENLA             Reviewed;         386 AA.
AC   Q0IH73;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Short-chain dehydrogenase/reductase family 42E member 1 {ECO:0000250|UniProtKB:Q8WUS8};
DE            EC=1.1.1.-;
GN   Name=sdr42e1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family. {ECO:0000305}.
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DR   EMBL; BC123279; AAI23280.1; -; mRNA.
DR   RefSeq; NP_001090495.1; NM_001097026.1.
DR   AlphaFoldDB; Q0IH73; -.
DR   SMR; Q0IH73; -.
DR   MaxQB; Q0IH73; -.
DR   DNASU; 779408; -.
DR   GeneID; 779408; -.
DR   KEGG; xla:779408; -.
DR   CTD; 779408; -.
DR   Xenbase; XB-GENE-985968; sdr42e1.L.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 779408; Expressed in blastula and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Membrane; NAD; Oxidoreductase; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..386
FT                   /note="Short-chain dehydrogenase/reductase family 42E
FT                   member 1"
FT                   /id="PRO_0000331759"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        150
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         154
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   386 AA;  43610 MW;  3855B1CEFEB4E2C2 CRC64;
     MSSSQRAKET VVITGGGGYF GHRLGCTLHE KGVHVILFDI RKPDQELPEG IHFVQGDVRS
     LSQLEDVVAG ASCVFHTASY GMSGKEQLHR QKIEAINVRG TENIIQACIN TNVPRLVYTS
     TFNVIFGGQT IRDGDESLPY LPQDAFVDNY SRTKTVAEMF VLKMNNQELK NNSGFLRTCS
     LRAAGIYGPG EQRHLPRIIS ALEKGMFLFV YGDNPLVQFV HVDNLISAHI LAAEALTSEK
     KYIAAGQPYF ISDGPPVNNF EFFRPLVEGL GYKFPSLRFP LSLVYFFAFL TEWIHFFISP
     VCDFQPILTR AEVFKTGVTH YFKIEKATRE LGFEPQPFTM QDVAEWFKNH GYGKQDKKIK
     SNYLIWDIIF ILLVTVVLLS WLPSSE