ID   D42E2_HUMAN             Reviewed;         422 AA.
AC   A6NKP2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 3.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Putative short-chain dehydrogenase/reductase family 42E member 2;
DE            EC=1.1.1.-;
GN   Name=SDR42E2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA   Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA   Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA   Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M., Thornton J.M.,
RA   Adamski J., Oppermann U.;
RT   "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT   nomenclature initiative.";
RL   Chem. Biol. Interact. 178:94-98(2009).
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC009019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A6NKP2; -.
DR   SMR; A6NKP2; -.
DR   IntAct; A6NKP2; 2.
DR   STRING; 9606.ENSP00000473474; -.
DR   iPTMnet; A6NKP2; -.
DR   PhosphoSitePlus; A6NKP2; -.
DR   BioMuta; SDR42E2; -.
DR   jPOST; A6NKP2; -.
DR   PaxDb; A6NKP2; -.
DR   PeptideAtlas; A6NKP2; -.
DR   PRIDE; A6NKP2; -.
DR   ProteomicsDB; 1425; -.
DR   Antibodypedia; 72105; 3 antibodies from 3 providers.
DR   Ensembl; ENST00000602312.3; ENSP00000473474.2; ENSG00000183921.8.
DR   MANE-Select; ENST00000602312.3; ENSP00000473474.2; NM_001394319.2; NP_001381248.1.
DR   UCSC; uc059ryf.1; human.
DR   GeneCards; SDR42E2; -.
DR   HGNC; HGNC:35414; SDR42E2.
DR   HPA; ENSG00000183921; Group enriched (brain, choroid plexus, fallopian tube, pituitary gland, testis).
DR   neXtProt; NX_A6NKP2; -.
DR   VEuPathDB; HostDB:ENSG00000183921; -.
DR   eggNOG; KOG1430; Eukaryota.
DR   GeneTree; ENSGT00940000160393; -.
DR   HOGENOM; CLU_007383_6_8_1; -.
DR   InParanoid; A6NKP2; -.
DR   OMA; LWDVVNY; -.
DR   PhylomeDB; A6NKP2; -.
DR   TreeFam; TF313574; -.
DR   PathwayCommons; A6NKP2; -.
DR   SignaLink; A6NKP2; -.
DR   ChiTaRS; SDR42E2; human.
DR   Pharos; A6NKP2; Tdark.
DR   PRO; PR:A6NKP2; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; A6NKP2; protein.
DR   Bgee; ENSG00000183921; Expressed in right uterine tube and 32 other tissues.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..422
FT                   /note="Putative short-chain dehydrogenase/reductase family
FT                   42E member 2"
FT                   /id="PRO_0000334700"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        176
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         180
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   422 AA;  46869 MW;  24AC990529434BDC CRC64;
     MKSNPPRSSL EACKAAGQAP QQKTQAKPTK AARQKVLVTG GGGYLGFSLG SHLAKSGTSV
     ILLDRRRPQW ELSPETKFIQ ADVRDEEALY RAFEGVDCVF HVASYGMSGA EKLQKEQIES
     INVGGTKLVI DVCVRRRVPR LIYTSTVNVA FGGKPIEQGD EDSVPYFPLD EHVDHYSRTK
     AIADQLTLMA NGMPLPGGGT LRTCVLRPPG IYGPEEQRHL PRVAGHIKKR LFMFRFGDHK
     ARMNWVHVHN LVQAHVLAAE ALTTAKGYVA SGQAYYINDG ESVNLFEWMA PLFEKLGYSQ
     PWIQVPTSWV YLTAAVMERL HLALRPICSL PPLLTRSEVR SVAVTHTFQI AKARAQLGYA
     PDKFRFADAV ELYVQSTTRR PRGSTARTLL RLLLRLLLFL GLLALALHFL GLQPLHAAVE
     RL