ID   D5_FOWPN                Reviewed;         791 AA.
AC   P21969; Q9J5F1;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2001, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Primase D5;
DE            EC=3.6.4.-;
GN   OrderedLocusNames=FPV058; ORFNames=FPD5;
OS   Fowlpox virus (strain NVSL) (FPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX   NCBI_TaxID=928301;
OH   NCBI_TaxID=7742; Vertebrata.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FP-1;
RX   PubMed=2165135; DOI=10.1099/0022-1317-71-7-1517;
RA   Tartaglia J., Winslow J., Goebel S.J., Johnson G.P., Taylor J.,
RA   Paoletti E.;
RT   "Nucleotide sequence analysis of a 10.5 kbp HindIII fragment of fowlpox
RT   virus: relatedness to the central portion of the vaccinia virus HindIII D
RT   region.";
RL   J. Gen. Virol. 71:1517-1524(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10729156; DOI=10.1128/jvi.74.8.3815-3831.2000;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "The genome of fowlpox virus.";
RL   J. Virol. 74:3815-3831(2000).
CC   -!- FUNCTION: Primase which may have roles in initiation of DNA replication
CC       or lagging-strand synthesis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with A20. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae D5 family. {ECO:0000305}.
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DR   EMBL; X17202; CAA35068.1; -; Genomic_DNA.
DR   EMBL; AF198100; AAF44402.1; -; Genomic_DNA.
DR   PIR; E35216; E35216.
DR   RefSeq; NP_039021.1; NC_002188.1.
DR   PRIDE; P21969; -.
DR   GeneID; 1486606; -.
DR   KEGG; vg:1486606; -.
DR   Proteomes; UP000008597; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004968; DNA_primase/NTPase_C.
DR   InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014818; Phage/plasmid_primase_P4_C.
DR   Pfam; PF08706; D5_N; 1.
DR   Pfam; PF03288; Pox_D5; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51206; SF3_HELICASE_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..791
FT                   /note="Primase D5"
FT                   /id="PRO_0000099442"
FT   DOMAIN          479..641
FT                   /note="SF3 helicase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00551"
FT   REGION          346..471
FT                   /note="Primase"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        174
FT                   /evidence="ECO:0000255"
FT   BINDING         505..512
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00551"
FT   CONFLICT        565
FT                   /note="C -> Y (in Ref. 1; CAA35068)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   791 AA;  92595 MW;  349147DB081A4FF1 CRC64;
     MALSVIRNNH IIFVLKQIGV RTKHRENNNS KYVESFTCDE LERYIYSNPD CTLFETLKDE
     EYYSNVRVFF DVDMDGRLDD KYQATHNFVN IITKFVADYA YNDCKMISNH RDKDKMITDM
     KSNFSITEST DKEKTSFHLI FFNCYTTLDT LINMRKKLIV LTKESNNRLV KAIDTSVYRH
     KPSLRIVGTK KDSINIHVHK KTKQNIHFKN YLFTYVDYNE EDCYYFVSEQ QHQSPDLLNW
     KEEYIPFHDA IKKISKAIGN SIINLKDITA ENFTVTPLDI YYATPCNLCK KVSHKHPHHL
     LISNDCIRIY KSGNPNSCKI KTISLEGNKL FSISQQIIDL NVINVSDRGE YLVWLKNVWR
     MCEDDNNITK LILYMRDHLS SDCTDLLLCP RNRKVIEHNL KDMLIDTIET DTYPEKLQFL
     NGVYDIKDSI FYQGNDAKKF VCTVSTGYKY EEGINVDDIT TELMSILDDI QPKTKENFEN
     RELYEQILSS CLMGTTKQCI FFFYGETATG KSTTKKLLKS VMHNMFLETG QVILTEQMDK
     GPNPFIANMH LKRVVFCSEL PDFSCNTSKK IRSDNIKKLT EPCVVGRSCY SNKINNRNHA
     TIIIDTNYKP VFDKVDNAIM RRIALVNFKT HFTNTKKKVH NSKYDFIKPL NESLDSKIQS
     NYFRYAFLKI LLGWFSKYHV PNLRILPTPD KIPDFKFRLK VESLIIPSNS THVKYVDKLM
     KLGYITDDDG IPVLQLNIFQ QKLSLHFNVK LYGQDIDSFI MKNKKYMNLA DEYMSFIFIE
     DLNTINEPRN T