ID   DAA10_BOVIN             Reviewed;         357 AA.
AC   Q29RZ9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Dynein axonemal assembly factor 10 {ECO:0000305};
DE   AltName: Full=WD repeat-containing protein 92;
GN   Name=DNAAF10; Synonyms=WDR92;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key assembly factor specifically required for the stability
CC       of axonemal dynein heavy chains in cytoplasm.
CC       {ECO:0000250|UniProtKB:A8J3F6}.
CC   -!- SUBUNIT: Component of the PAQosome complex which is responsible for the
CC       biogenesis of several protein complexes and which consists of R2TP
CC       complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members
CC       PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and
CC       DNAAF10/WDR92 (By similarity). Interacts with PIH1D1; the interaction
CC       associates DNAAF10 with the R2TP complex (By similarity). Interacts
CC       with several dynein axonemal assembly factors (By similarity).
CC       {ECO:0000250|UniProtKB:A8J3F6, ECO:0000250|UniProtKB:Q96MX6}.
CC   -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:A8J3F6}.
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DR   EMBL; BC113293; AAI13294.1; -; mRNA.
DR   RefSeq; NP_001039930.1; NM_001046465.1.
DR   AlphaFoldDB; Q29RZ9; -.
DR   SMR; Q29RZ9; -.
DR   STRING; 9913.ENSBTAP00000014007; -.
DR   PaxDb; Q29RZ9; -.
DR   PRIDE; Q29RZ9; -.
DR   Ensembl; ENSBTAT00000014007; ENSBTAP00000014007; ENSBTAG00000010595.
DR   GeneID; 540032; -.
DR   KEGG; bta:540032; -.
DR   CTD; 116143; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010595; -.
DR   VGNC; VGNC:50103; DNAAF10.
DR   eggNOG; ENOG502QRKB; Eukaryota.
DR   GeneTree; ENSGT00950000183091; -.
DR   HOGENOM; CLU_062543_0_0_1; -.
DR   InParanoid; Q29RZ9; -.
DR   OMA; RWEATMK; -.
DR   OrthoDB; 1030954at2759; -.
DR   TreeFam; TF351064; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000010595; Expressed in caput epididymis and 105 other tissues.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; IEA:Ensembl.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..357
FT                   /note="Dynein axonemal assembly factor 10"
FT                   /id="PRO_0000301670"
FT   REPEAT          63..105
FT                   /note="WD 1"
FT   REPEAT          115..154
FT                   /note="WD 2"
FT   REPEAT          162..205
FT                   /note="WD 3"
FT   REPEAT          207..249
FT                   /note="WD 4"
FT   REPEAT          257..297
FT                   /note="WD 5"
FT   REPEAT          319..357
FT                   /note="WD 6"
SQ   SEQUENCE   357 AA;  39818 MW;  3C1194FEC5E1C1B3 CRC64;
     MSAFEKPQII SHIQKSLSYT VFDCKWMPCS AKFVTMGNFA RGTGVIQLYE IQQGDLKLLR
     EIEKAKPIKC GTFGATSLQQ RYLATGDFAG NLHIWNLEAP EVPVYSVKGH KEIINTIDGV
     GGLGIGEGAP EIVTGSRDGT VKVWDPRQKD DPVANMEPVQ GENKRDCWTV AFGNAYNQEE
     RVVCAGYDNG DIKLFDLRNM SLRWETNIKN GVCSLEFDRK DISMNKLVAT SLEGKFHVFD
     MRTQHPTKGF ASVSEKAHKS TVWQVRHLPQ NREVFLTAGG AGSLHLWKYE YPIQRSKKDS
     EGVEMGVAGS VSLLQNVTLS TQPVSSLDWS PDKRGLCICS SFDQMVRVLI VTKLHKI