ID   DAA10_CHLRE             Reviewed;         358 AA.
AC   A8J3F6;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Dynein axonemal assembly factor 10 {ECO:0000305};
DE   AltName: Full=WD repeat-containing protein 92 {ECO:0000303|PubMed:30428028, ECO:0000303|PubMed:31116681};
GN   Name=dnaaf10;
GN   Synonyms=wdr92 {ECO:0000303|PubMed:30428028, ECO:0000303|PubMed:31116681};
GN   ORFNames=CHLRE_16g672600v5 {ECO:0000312|EMBL:PNW72329.1},
GN   CHLREDRAFT_191514 {ECO:0000312|EMBL:EDP01251.1};
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1] {ECO:0000312|EMBL:EDP01251.1, ECO:0000312|Proteomes:UP000006906}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-142 {ECO:0000312|EMBL:EDP01251.1}, and
RC   CC-503 {ECO:0000312|Proteomes:UP000006906};
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA   Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA   Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA   Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA   Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA   Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA   Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA   Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA   Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA   Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA   Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA   Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA   Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA   Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA   Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA   Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA   Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and plant
RT   functions.";
RL   Science 318:245-250(2007).
RN   [2] {ECO:0000312|EMBL:PNW72329.1}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC PRA-142 {ECO:0000312|EMBL:PNW72329.1};
RG   Chlamydomonas Annotation Team;
RG   JGI Annotation Team;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA   Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA   Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA   Grimwood J., Schmutz J., Grigoriev I.V., Rokhsar D.S.;
RT   "WGS assembly of Chlamydomonas reinhardtii.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   DISRUPTION PHENOTYPE, FUNCTION, INTERACTION WITH R2TP COMPLEX, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=30428028; DOI=10.1093/jmcb/mjy067;
RA   Liu G., Wang L., Pan J.;
RT   "Chlamydomonas WDR92 in association with R2TP-like complex and multiple
RT   DNAAFs to regulate ciliary dynein preassembly.";
RL   J. Mol. Cell Biol. 11:770-780(2019).
RN   [4]
RP   FUNCTION.
RX   PubMed=31116681; DOI=10.1091/mbc.e19-03-0139;
RA   Patel-King R.S., Sakato-Antoku M., Yankova M., King S.M.;
RT   "WDR92 is required for axonemal dynein heavy chain stability in
RT   cytoplasm.";
RL   Mol. Biol. Cell 30:1834-1845(2019).
CC   -!- FUNCTION: Key assembly factor specifically required for the stability
CC       of axonemal dynein heavy chains in cytoplasm.
CC       {ECO:0000269|PubMed:31116681}.
CC   -!- SUBUNIT: Interacts with PIH1D1; the interaction associates DNAAF10 with
CC       the R2TP complex (Probable). Interacts with several dynein axonemal
CC       assembly factors (PubMed:30428028). {ECO:0000269|PubMed:30428028,
CC       ECO:0000305|PubMed:30428028}.
CC   -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC       {ECO:0000305|PubMed:30428028}.
CC   -!- DISRUPTION PHENOTYPE: Mutants show ciliary loss with disappearance of
CC       axonemal dynein arms and diminishment of dynein arm heavy chains in the
CC       cytoplasm. They have reduced beat frequency and dyskinetic motion of
CC       the remaining ventral cilia. {ECO:0000269|PubMed:30428028}.
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DR   EMBL; DS496135; EDP01251.1; -; Genomic_DNA.
DR   EMBL; CM008977; PNW72329.1; -; Genomic_DNA.
DR   RefSeq; XP_001695914.1; XM_001695862.1.
DR   AlphaFoldDB; A8J3F6; -.
DR   SMR; A8J3F6; -.
DR   STRING; 3055.EDP01251; -.
DR   PaxDb; A8J3F6; -.
DR   PRIDE; A8J3F6; -.
DR   EnsemblPlants; PNW72329; PNW72329; CHLRE_16g672600v5.
DR   GeneID; 5721407; -.
DR   Gramene; PNW72329; PNW72329; CHLRE_16g672600v5.
DR   KEGG; cre:CHLRE_16g672600v5; -.
DR   eggNOG; ENOG502QRKB; Eukaryota.
DR   HOGENOM; CLU_062543_0_0_1; -.
DR   InParanoid; A8J3F6; -.
DR   OMA; RWEATMK; -.
DR   OrthoDB; 1030954at2759; -.
DR   Proteomes; UP000006906; Chromosome 16.
DR   GO; GO:0120293; C:dynein axonemal particle; IDA:UniProtKB.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; IDA:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..358
FT                   /note="Dynein axonemal assembly factor 10"
FT                   /id="PRO_0000452688"
FT   REPEAT          63..105
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          109..154
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          162..205
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          207..249
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          258..298
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          320..358
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   358 AA;  39664 MW;  A515B083DC4ACD83 CRC64;
     MDLQNKPQIL EHLHKSLTVT LYDCRWIPGT AKFVTLGSYA RNTGCLQVYE LEGPDLKTVK
     ETEKKHSFKC GTFGASSLAE RRLATGNFGG EVQIWDLENT AQPVFTAQAH ASIVNAIDGC
     GGQAKGYGAP ELATCGRDGC VRVWDVRQQD APVAAFEPAD PNNVRDCWCV AFGNSFNDNE
     RCLLAGYDNG DVKMFDLRMN KVRWETNVRN GVCGLQFDRK DISMNKFAVC CLEAQFHVFD
     ARTQHPKKGF ASVSEKITAG ATVWGAQHLP QNREVFMVSA GDGNLYLYKY HYPDQRKVKD
     HDGQELGVAG SVEMLNYKNI STQPVAGFDW SPDKEGLFAC VAFDQAVRVG IVTKLNKV