ID   DAA10_DANRE             Reviewed;         358 AA.
AC   Q561Y0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Dynein axonemal assembly factor 10 {ECO:0000305};
DE   AltName: Full=WD repeat-containing protein 92;
GN   Name=dnaaf10; Synonyms=wdr92; ORFNames=zgc:110253;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key assembly factor specifically required for the stability
CC       of axonemal dynein heavy chains in cytoplasm.
CC       {ECO:0000250|UniProtKB:A8J3F6}.
CC   -!- SUBUNIT: Interacts with PIH1D1; the interaction associates DNAAF10 with
CC       the R2TP complex (By similarity). Interacts with several dynein
CC       axonemal assembly factors (By similarity).
CC       {ECO:0000250|UniProtKB:A8J3F6, ECO:0000250|UniProtKB:Q96MX6}.
CC   -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:A8J3F6}.
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DR   EMBL; BC092828; AAH92828.1; -; mRNA.
DR   RefSeq; NP_001017621.1; NM_001017621.1.
DR   AlphaFoldDB; Q561Y0; -.
DR   SMR; Q561Y0; -.
DR   STRING; 7955.ENSDARP00000054317; -.
DR   PaxDb; Q561Y0; -.
DR   DNASU; 550284; -.
DR   Ensembl; ENSDART00000054318; ENSDARP00000054317; ENSDARG00000037334.
DR   GeneID; 550284; -.
DR   KEGG; dre:550284; -.
DR   CTD; 116143; -.
DR   ZFIN; ZDB-GENE-050417-93; dnaaf10.
DR   eggNOG; ENOG502QRKB; Eukaryota.
DR   GeneTree; ENSGT00950000183091; -.
DR   HOGENOM; CLU_062543_0_0_1; -.
DR   InParanoid; Q561Y0; -.
DR   OMA; RWEATMK; -.
DR   OrthoDB; 1030954at2759; -.
DR   PhylomeDB; Q561Y0; -.
DR   TreeFam; TF351064; -.
DR   PRO; PR:Q561Y0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000037334; Expressed in testis and 27 other tissues.
DR   ExpressionAtlas; Q561Y0; baseline and differential.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..358
FT                   /note="Dynein axonemal assembly factor 10"
FT                   /id="PRO_0000301673"
FT   REPEAT          64..106
FT                   /note="WD 1"
FT   REPEAT          116..155
FT                   /note="WD 2"
FT   REPEAT          163..206
FT                   /note="WD 3"
FT   REPEAT          208..250
FT                   /note="WD 4"
FT   REPEAT          258..298
FT                   /note="WD 5"
FT   REPEAT          320..358
FT                   /note="WD 6"
SQ   SEQUENCE   358 AA;  39738 MW;  C8028F4BBA08A35A CRC64;
     MSAALEKPQI IAHIQKSLNY TVFESKWIPC SAKFVCMGNF ARGTGVMQIY EIQHGELQLV
     REIEKSKPIK CGTFGATSLQ QRHLATGDFD GNLNVWNLEV PDSPVYSVKA HKEIINAIDG
     VGGLGIGDGA PEIVTGSRDG TVKVWDSRQK DTPVVNMEPT EGETKRDCWT VAFGHAFNDQ
     DRCVCAGYDN GDIKLFDLRN MSLRWEKNIR NGVCSVEFDR KDINMNKLVA TSLEGKFHVF
     DMRTQHPSKG FASVSEKAHK STIWQVRHLP QNRDVFMTAG GAGNLHLWKY EYPAQRSKKG
     ADDVEMGVAG SVNLLQNVTL STQPISSLDW SPDKQGLCVC SSFDQSVRVL IVTKLNTV