ID   DAA10_DICDI             Reviewed;         357 AA.
AC   Q54E33;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Dynein axonemal assembly factor 10 {ECO:0000305};
DE   AltName: Full=WD repeat-containing protein 92 homolog;
GN   Name=dnaaf10; Synonyms=wdr92; ORFNames=DDB_G0291822;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Key assembly factor specifically required for the stability
CC       of axonemal dynein heavy chains in cytoplasm.
CC       {ECO:0000250|UniProtKB:A8J3F6}.
CC   -!- SUBUNIT: Interacts with PIH1D1; the interaction associates DNAAF10 with
CC       the R2TP complex (By similarity). Interacts with several dynein
CC       axonemal assembly factors (By similarity).
CC       {ECO:0000250|UniProtKB:A8J3F6, ECO:0000250|UniProtKB:Q96MX6}.
CC   -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:A8J3F6}.
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DR   EMBL; AAFI02000185; EAL61532.1; -; Genomic_DNA.
DR   RefSeq; XP_629954.1; XM_629952.1.
DR   AlphaFoldDB; Q54E33; -.
DR   SMR; Q54E33; -.
DR   STRING; 44689.DDB0267167; -.
DR   PaxDb; Q54E33; -.
DR   EnsemblProtists; EAL61532; EAL61532; DDB_G0291822.
DR   GeneID; 8628360; -.
DR   KEGG; ddi:DDB_G0291822; -.
DR   dictyBase; DDB_G0291822; wdr92.
DR   eggNOG; ENOG502QRKB; Eukaryota.
DR   HOGENOM; CLU_062543_0_0_1; -.
DR   InParanoid; Q54E33; -.
DR   OMA; WSICTND; -.
DR   PhylomeDB; Q54E33; -.
DR   PRO; PR:Q54E33; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..357
FT                   /note="Dynein axonemal assembly factor 10"
FT                   /id="PRO_0000328014"
FT   REPEAT          80..127
FT                   /note="WD 1"
FT   REPEAT          132..170
FT                   /note="WD 2"
FT   REPEAT          184..223
FT                   /note="WD 3"
FT   REPEAT          277..321
FT                   /note="WD 4"
SQ   SEQUENCE   357 AA;  39692 MW;  A2E06D106A140BFA CRC64;
     MSALGESNNK QNGKEILHNY VTKKLTSQPY SCQWIPTSCS VVTVGKKTSG GISKGDIKIH
     QLEFDDTSGD PKLNLVYENE FTNPFRCLSF FKQANQLQQQ DNRKFITGDF NGQISEWDSD
     ICDIPIWGVK GAHQGSISAI DAYADNLVVC GGKDGTIKVY DTRIKPNSAN DNNGNNSSPI
     STFEQTNKSN CWSICTNDNN IIAGFENGDL NIYNLKTNSI QSTTKLNGGI CSIDSNDRSN
     ILNQFLITTN KSFISIASFN NNNNNNIEFK DYDINKEPNQ TIWSGIYSPW NKKDNENIFT
     IAQGDGSVSM YRDDCKLIDK VLVSDLPILS LDYSKDRKGL LCCISLKKQL SILISPC