DAA10_MOUSE
ID DAA10_MOUSE Reviewed; 357 AA.
AC Q8BGF3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Dynein axonemal assembly factor 10 {ECO:0000305};
DE AltName: Full=WD repeat-containing protein 92;
DE AltName: Full=WD repeat-containing protein Monad;
GN Name=Dnaaf10; Synonyms=Wdr92;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Key assembly factor specifically required for the stability
CC of axonemal dynein heavy chains in cytoplasm.
CC {ECO:0000250|UniProtKB:A8J3F6}.
CC -!- SUBUNIT: Component of the PAQosome complex which is responsible for the
CC biogenesis of several protein complexes and which consists of R2TP
CC complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members
CC PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and
CC DNAAF10/WDR92 (By similarity). Interacts with PIH1D1; the interaction
CC associates DNAAF10 with the R2TP complex (By similarity). Interacts
CC with several dynein axonemal assembly factors (By similarity).
CC {ECO:0000250|UniProtKB:A8J3F6, ECO:0000250|UniProtKB:Q96MX6}.
CC -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC {ECO:0000250|UniProtKB:A8J3F6}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK033294; BAC28225.1; -; mRNA.
DR EMBL; AK088218; BAC40217.1; -; mRNA.
DR EMBL; AL713926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC096540; AAH96540.1; -; mRNA.
DR CCDS; CCDS24450.1; -.
DR RefSeq; NP_849240.1; NM_178909.4.
DR AlphaFoldDB; Q8BGF3; -.
DR SMR; Q8BGF3; -.
DR BioGRID; 222163; 19.
DR IntAct; Q8BGF3; 2.
DR MINT; Q8BGF3; -.
DR STRING; 10090.ENSMUSP00000040938; -.
DR iPTMnet; Q8BGF3; -.
DR PhosphoSitePlus; Q8BGF3; -.
DR EPD; Q8BGF3; -.
DR MaxQB; Q8BGF3; -.
DR PaxDb; Q8BGF3; -.
DR PeptideAtlas; Q8BGF3; -.
DR PRIDE; Q8BGF3; -.
DR ProteomicsDB; 299760; -.
DR Antibodypedia; 48145; 112 antibodies from 23 providers.
DR Ensembl; ENSMUST00000046955; ENSMUSP00000040938; ENSMUSG00000078970.
DR GeneID; 103784; -.
DR KEGG; mmu:103784; -.
DR UCSC; uc007icd.1; mouse.
DR CTD; 116143; -.
DR MGI; MGI:2144224; Wdr92.
DR VEuPathDB; HostDB:ENSMUSG00000078970; -.
DR eggNOG; ENOG502QRKB; Eukaryota.
DR GeneTree; ENSGT00950000183091; -.
DR HOGENOM; CLU_062543_0_0_1; -.
DR InParanoid; Q8BGF3; -.
DR OMA; RWEATMK; -.
DR OrthoDB; 1030954at2759; -.
DR PhylomeDB; Q8BGF3; -.
DR TreeFam; TF351064; -.
DR BioGRID-ORCS; 103784; 22 hits in 73 CRISPR screens.
DR ChiTaRS; Wdr92; mouse.
DR PRO; PR:Q8BGF3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BGF3; protein.
DR Bgee; ENSMUSG00000078970; Expressed in spermatocyte and 229 other tissues.
DR Genevisible; Q8BGF3; MM.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; ISO:MGI.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..357
FT /note="Dynein axonemal assembly factor 10"
FT /id="PRO_0000301672"
FT REPEAT 63..105
FT /note="WD 1"
FT REPEAT 115..154
FT /note="WD 2"
FT REPEAT 162..205
FT /note="WD 3"
FT REPEAT 207..249
FT /note="WD 4"
FT REPEAT 257..297
FT /note="WD 5"
FT REPEAT 319..357
FT /note="WD 6"
SQ SEQUENCE 357 AA; 39790 MW; 9E16D75E087B8C28 CRC64;
MSTFEKPQII VHIQKGLNYT VFDSKWVPCS AKFVTMGNFA RGTGVIQVYE IQRGDLKLLR
EIEKAKPIKC GTFGAASLQQ RFLATGDFGG NLHIWNLEAP EMPVYSVKGH KEIINTIDGV
GGLGIGEGAP EIVTGSRDGT VKVWDPRQKE DPVANMEPAQ GENKRDCWTV AFGNAYNQEE
RVVCAGYDNG DIKLFDLRNM SLRWETNIKN GVCSLEFDRK DISMNKLVAT SLEGKFHVFD
MRTQHPTKGF ASVTEKAHKS TVWQVRHLPQ NREIFLTTGG AGSLHLWKYE YPTQRSKKDS
EGLEMGVAGS VSLLQNVTVS TQPISSLDWS PDKRGLCVCS SFDQMVRVLI VTKLQTI
